Pleiotropy

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pleiotropy

[plī′ä·trə·pē]
(genetics)
The quality of a gene having more than one phenotypic effect.

Pleiotropy

 

the multiple effect of a gene; the capacity of one hereditary factor—a gene—to affect simultaneously several different characters of an organism.

In the early development of Mendelism, when no radical distinction was made between the genotype and the phenotype, the idea of the single effect of the gene (“one gene, one character”) predominated. However, the relationship between the gene and a character has turned out to be much more complex. G. Mendel discovered that a single hereditary factor in pea plants can determine various characters: the red color of the flowers, the gray color of the seed pods, and the pink spot at the base of the leaves. It was subsequently shown that the manifestations of a gene can be diverse and that practically all genes that have been carefully studied are capable of pleiotropy, that is, each gene acts on the entire system of the developing organism and each hereditary character is determined by many genes (actually by the entire genotype). For example, the genes that determine the coat color of the house mouse also influence the body size, and the gene that influences eye pigmentation in the Mediterranean flour moth has another ten morphological and physiological manifestations.

Pleiotropy often extends to characters that have evolutionary significance, such as fertility, longevity, and the ability to survive under extreme environmental conditions. In Drosophila, many mutations that have been studied influence viability. The gene for white eyes also influences the color and shape of internal organs and decreases fertility and longevity. The significance of pleiotropy in evolution was emphasized as early as 1926 by S. S. Chetverikov: “The idea of the multiple effect of the gene (pleiotropy), introduced by Morgan, is extremely important for an understanding of the way natural selection is effected. This leads us to view the genotypic environment as a complex of genes that act internally and genetically on the manifestation of each gene in its character.”

Inasmuch as it is presumed that each gene, as a rule, has a single primary biochemical action, pleiotropy is explained by a hierarchical superstructure of secondary and tertiary gene interactions that lead to a broad spectrum of phenotypic characters that are not obviously related to each other. Pleiotropy is evidence of the interrelationship of cellular metabolism and the biochemical mechanisms of ontogeny. It also attests to the presence, between the primary action of a gene and its phenotypic manifestation, of many intermediate links, upon which other genes and environmental factors may exert influence.

REFERENCES

Malinovskii, A. A. “Rol’ geneticheskikh i fenogeneticheskikh iavlenii ν evoliutsii vida,” part 1. Izvestiia AN SSSR: Seriia biologicheskaia, 1939, issue 4.
Lobashev, M. E. Genetika, 2nd ed. Moscow, 1967.
Chetverikov, S. S. “O nekotorykh momentakh evoliutsionnogo protsessa s tochki zreniia sovremennoi genetiki.” In Klassiki sovetskoi genetiki Leningrad, 1968. Pages 133–70.
Serebrovskii, A. S. Nekotorye problemy organicheskoi Evoliutsii, ch. 4. Moscow, 1973.
References in periodicals archive ?
Para explicar la evolucion de organos genitales masculinos se han discutido tres hipotesis principales, la hipotesis llave-cerradura (Eberhard 1985, Arnqvist 1998), pleiotropia (Mayr 1963) y seleccion sexual (Eberhard 1985).
Teniendo en cuenta que la variacion intra e interpoblacional de la forma y el tamano del aedeagus es incluso mayor a la de otros caracteres no sexuales (alas y manchas), y que ademas existio correlacion positiva en el tamano del aedeagus y del ala es posible apoyar la hipotesis de pleiotropia segun la cual, los organos reproductivos tienen correlaciones positivas respecto a otros organos no relacionados que dependen del mismo gen y por tanto, se ven afectados por el proceso selectivo.
mediopunctata se ha reportado correlacion altamente positiva entre el tamano del cuerpo medido usando como parametro el ala y el aedeago, de acuerdo a esto, los autores proponen que para esta especie la evolucion de los genitales se ajusta a la hipotesis de pleiotropia y de seleccion sexual (Andrade et al.
A teoria da pleiotropia antagonista foi formulada por George Williams, em 1957 (7).
Apesar de haver mais evidencias favoraveis para a pleiotropia antagonista do que para o acumulo de mutacoes, os achados em seres humanos nao sao convincentes.