pleiotropic


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Related to pleiotropic: Pleiotropic Genes

pleiotropic

[‚plī·ə′träp·ik]
(genetics)
Referring to a gene or mutation that has multiple effects.
References in periodicals archive ?
Investigation of the vascular and Pleiotropic effects of atorvastatin and pioglitazone in a population at high cardiovascular risk.
Hence, KIT expression is related to the prevention of severe pleiotropic effects on other tissues caused by the gene duplication in I/I (KIT).
sup][8] Thus, IL-21 has pleiotropic effects on the regulation of inflammation by affecting these cells.
Thus, metformin appears to have very important effects on the human gut microbiome that contribute to its pleiotropic beneficial antidiabetic effects, but an individual's tolerance to metformin can also be influenced by their inherent gut microbiome.
We propose to 1) use the formation of invadosomes, characteristic acto-adhesive structures important for cell invasion as a specific cellular function, to address these fundamental questions 2) and target the pleiotropic tyrosine kinase Src that has the ability to induce cell invasion globally by acting on cell adhesion, migration, contractility and invadosome dynamics independently of any environmental regulation, to investigate how a biological signal can be dynamically encoded into specific multifarious cellular outputs.
This study, using Mendelian randomization and sophisticated analyses to adjust for pleiotropic effects, advances our knowledge; however, it seems that other approaches are required to further evaluate the causal relevance of each of these lipid fractions in association with type 2 diabetes.
Other topics include the transcriptional control of dendritic cell development, the genomics of immune diseases and new therapies, chemokines and chemokine receptors in lymphoid tissue dynamics, the innate lymphoid cell precursor, retinoic acid and retinoic acid receptors as pleiotropic modulators of the immune system, auto-antigens as partners in the initiation and propagation of autoimmune rheumatic diseases, fate mapping and quantitation of hematopoiesis in vivo, coinhibitory pathways in immunotherapy for cancer, and broadly neutralized antibodies to HIV and their role in vaccine design.
Along with weight loss, additional beneficial effects on blood pressure and lipids might be achieved due to the pleiotropic effects of liraglutide.
Bioactive food ingredients, because of their pleiotropic effects, may affect multiple targets, thereby helping to alleviate cancer growth and progression, alone or in combination with current drugs, while reducing toxicity.
Pleiotropic effects of statins in atherosclerotic disease: focus on the antioxidant activity of atorvastatin.
Considering the higher risk of coronary events before and after PCI and statins' pleiotropic effects, it is reasonable to investigate the optimal time for starting statins in patients with ACS.