pleiotropic


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Related to pleiotropic: Pleiotropic Genes

pleiotropic

[‚plī·ə′träp·ik]
(genetics)
Referring to a gene or mutation that has multiple effects.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
From these findings, it was concluded that this locus had pleiotropic effects on a number of morphological traits and this affected rice yield under salt stress conditions.
Statins inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in the multistep mevalonate cascade for cholesterol synthesis.[17] Statins are widely used in the prevention of cardiovascular disease by lowering cholesterol.[17] Beyond their cholesterol reduction effect, statins have been shown to have pleiotropic effects.[15],[16],[17] Accumulating evidences indicated that the inhibition of the mevalonate pathway by statins induced ER stress and apoptosis in cancerous and noncancerous cells.[17],[18],[19],[20] In this study, we explored the beneficial effect of simvastatin on ox-LDL-induced ER stress and apoptosis in human vascular endothelial cells.
However, further evaluation is needed to identify appropriate agents and adequate doses to provide optimal therapeutic efficacy including the pleiotropic effect of statins for each individual patient's condition.
Hence, KIT expression is related to the prevention of severe pleiotropic effects on other tissues caused by the gene duplication in I/I (KIT).
Pleiotropic actions of peroxisome proliferator activated receptors (PPARs) in dysregulated metabolic homeostasis, inflammation and cancer: current evidence and future perspectives.
"Regarding the shared familial factors, I'm tempted to hypothesize that this might involve pleiotropic effects reflecting genetic variants associated with impulsivity," said Dr.
Rather, the strong implication is that the explanation for the observed preventive effect lies in the pleiotropic effects of the statin therapy routinely prescribed in accordance with guidelines once women received the diagnosis of hyperlipidemia, he continued.
Facing the pleiotropic properties of MSC like modulation of immune responses and alleviation of inflammation and tissue damage, as well as stimulation of tissue regeneration, it will be the goal of future efforts using relevant cell or animal model systems to unequivocally elucidate the molecular and cellular impact of a defined MSC population on a specified disease environment before their clinical application.
Many studies have reported the cholesterol-lowering effects of statins [4, 5], which exert pleiotropic effects including renoprotection [6].
MSC-1 is a first-in-class antibody that targets leukemia inhibitory factor, a pleiotropic cytokine that is overexpressed in certain solid tumors.
Metformin is a biguanide derivate and has pleiotropic effects (1).