Pleiotropy


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Related to Pleiotropy: pleiotropism, epistasis

pleiotropy

[plī′ä·trə·pē]
(genetics)
The quality of a gene having more than one phenotypic effect.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Pleiotropy

 

the multiple effect of a gene; the capacity of one hereditary factor—a gene—to affect simultaneously several different characters of an organism.

In the early development of Mendelism, when no radical distinction was made between the genotype and the phenotype, the idea of the single effect of the gene (“one gene, one character”) predominated. However, the relationship between the gene and a character has turned out to be much more complex. G. Mendel discovered that a single hereditary factor in pea plants can determine various characters: the red color of the flowers, the gray color of the seed pods, and the pink spot at the base of the leaves. It was subsequently shown that the manifestations of a gene can be diverse and that practically all genes that have been carefully studied are capable of pleiotropy, that is, each gene acts on the entire system of the developing organism and each hereditary character is determined by many genes (actually by the entire genotype). For example, the genes that determine the coat color of the house mouse also influence the body size, and the gene that influences eye pigmentation in the Mediterranean flour moth has another ten morphological and physiological manifestations.

Pleiotropy often extends to characters that have evolutionary significance, such as fertility, longevity, and the ability to survive under extreme environmental conditions. In Drosophila, many mutations that have been studied influence viability. The gene for white eyes also influences the color and shape of internal organs and decreases fertility and longevity. The significance of pleiotropy in evolution was emphasized as early as 1926 by S. S. Chetverikov: “The idea of the multiple effect of the gene (pleiotropy), introduced by Morgan, is extremely important for an understanding of the way natural selection is effected. This leads us to view the genotypic environment as a complex of genes that act internally and genetically on the manifestation of each gene in its character.”

Inasmuch as it is presumed that each gene, as a rule, has a single primary biochemical action, pleiotropy is explained by a hierarchical superstructure of secondary and tertiary gene interactions that lead to a broad spectrum of phenotypic characters that are not obviously related to each other. Pleiotropy is evidence of the interrelationship of cellular metabolism and the biochemical mechanisms of ontogeny. It also attests to the presence, between the primary action of a gene and its phenotypic manifestation, of many intermediate links, upon which other genes and environmental factors may exert influence.

REFERENCES

Malinovskii, A. A. “Rol’ geneticheskikh i fenogeneticheskikh iavlenii ν evoliutsii vida,” part 1. Izvestiia AN SSSR: Seriia biologicheskaia, 1939, issue 4.
Lobashev, M. E. Genetika, 2nd ed. Moscow, 1967.
Chetverikov, S. S. “O nekotorykh momentakh evoliutsionnogo protsessa s tochki zreniia sovremennoi genetiki.” In Klassiki sovetskoi genetiki Leningrad, 1968. Pages 133–70.
Serebrovskii, A. S. Nekotorye problemy organicheskoi Evoliutsii, ch. 4. Moscow, 1973.
The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Observed genotypic correlations may be due to pleiotropy, linkage disequilibrium, or drift.
Further research will be necessary to determine if these coincident QTL are due to close linkage or pleiotropy. More recent work on a doubled haploid population derived from a cross between Chevron and the cultivar Stander has also identified QTL associated with FHB resistance (Ma et al., 2000).
However, it is difficult to distinguish between the various theories of the maintenance of genetic variation (mutation-selection balance, balancing selection, antagonistic pleiotropy, environmental heterozygosity) simply by using observations of trait means and variances.
Therefore, these correlated responses are probably not merely due to linkage effects but also to pleiotropy, i.e., to the fact that high leaf ABA concentration and high sensitivity to drought are determined to a certain extent by a common set of genes.
Consistency across traits in the type of gene action at locus ugac540 (partial dominance of the P13 allele) on linkage group 8A strongly suggested that pleiotropy was the cause for the association among the three traits at this locus.
Tests to distinguish between pleiotropy and linkage have been developed (Jiang and Zeng 1995), but were not applied in this case because the markers used in this experiment are not sufficiently close together to provide a satisfactory level of resolution.
The "general vigor" problem: can antagonistic pleiotropy be detected when genetic covariances are positive?
Negative mutational covariances involving pupa-to-adult viability suggest antagonistic pleiotropy of some of the mutations involved.
This may be due to genes added to the modified organisms and their modified expression, or to genes affecting multiple characteristics (pleiotropy) that may disrupt the function of natural genes.
The complexity arises from 3 distinct genetic phenomena: pleiotropy, penetrance and expressivity (Table 1).
Other theories of oncocyte formation include Medawar's mutation accumulation hypothesis, Kirkwood's disposable soma theory and the concept of antagonistic pleiotropy. They have described the changes observed could be because of mutation in mitochondrial DNA.