podophyllin


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podophyllin

[‚päd·ə′fil·ən]
(pharmacology)
A light yellow to greenish-yellow or light brown powder with a bitter taste; soluble in alcohol, ether, and ammonium hydroxide; used in medicine. Also known as podophyllum resin.
References in periodicals archive ?
352/640(55%) patients were treated with topical 20% podophyllin cream and 288/640 patients(45%) were treated with 5% topical imiquimod cream (Table 20); 238/352 (67.6%) patients treated with podophyllin showed complete healing of lesion in comparison to 32.3% patients treated with 5% imiquimod showing complete response (Table 21).
Podophyllin use began in the 1800s, variously as an emetic and cathartic agent to an antivenom and suicidal agent.
Lynch said vulvar warts should be treated in pregnant women, but he warned that podophyllin and its derivatives should not be used.
As with the antiviral agents and podophyllin, hairy leukoplakia often recurs several weeks after successful retinoic acid therapy.
Warts are currently being treated by freezing, electrocautery, surgery, laser removal, or drugs such as podophyllin, interferon, or trichloroacetic acid.
Your dermatologist may prescribe a form of podophyllin which can be used at home.
Small, localized external lesions can be managed with four-six weekly applications of 20% Podophyllin. Halogenated acetic acid also can be used and may be less painful than Podophyllin.[22] Cryotherapy, using liquid nitrogen, as well as surgical removal of warts also are options.
Topical keratolytics, 5-flurouracil, corticosteroids, imiquimod, Vit.D analogues, oral and topical retinoids, podophyllin, intralesional bleomycin, electrocautery, dermabrasion, cryosurgery, CO2 laser, and wide surgical excision are various treatment modalities that yield only symptomatic improvement without affecting the lesion itself much (1-3).
The outcome of most of the children with domestic accidents were non-fatal (96.8%) but 1% resulted in death and 1% had hypoxic ischemic sequelae secondary to podophyllin poisoning.
A resin, known as Indian Podophyllum Resin is produced by the rhizome which is processed to yield a neurotoxin known as podophyllotoxin, or podophyllin. It prevents tumor growth, therefore used to synthesize teniposides (Giri et al., 2000) and etoposides (Canel et al., 2000).
Podophyllin toxicity may cause thrombocytopenia and leucopenia.