Recent research indicates a remarkable cure rate by topical application of podophyllotoxin
to certain carcinomas.
Jiang et al., "In vitro anti-tumour activity of stearic acid-g-chitosan oligosaccharide polymeric micelles loading podophyllotoxin
," Journal of Microencapsulation, vol.
(Figure 2), one of the main active components of J.
Shri Ram had done research on various aspects of literature growth in Podophyllotoxin
, like publication pattern, language of publications, authorship pattern, and country wise production and so on.
The therapy includes topical measures: immunomodulators (imiquimod), keratolitic agents (antimitotic podophyllotoxin
0.5% solution, trichloracetic solution, salycilic acid), antimetabolites (fluorouracil), sinecatechins.
In the past, several clinically established anticancer drugs such as vinblastine, paclitaxel, podophyllotoxin
and camptothecin were isolated from plants (Desai et al., 2008).
Evaluation of cytotoxic potential of latex of Calotropis procera and Podophyllotoxin
in Allium cepa.
Dual extraction of essential oil and podophyllotoxin
from creeping juniper (Juniperus horizontalis).
Issell, "The podophyllotoxin
derivatives VP16-213 and VM26," Cancer Chemotherapy and Pharmacology, vol.
 The active constituent of the drug is podophyllotoxin
, a lipid-soluble compound extracted from the resin of Podophyllin plant roots, which readily crosses cell membranes.
Topical application of podophyllotoxin
, imiquimod, trichloroacetic acid, and catechin has been tried, but its exact role in preventing recurrence is not known.
To begin with, the compounds from higher plants include Berbamine, Butulinic acid, Camptothecin, Cucurbitacin, Ellipticine, Flavopiridol, Homoharringtonine, Silvestrol, Berberine, Daphnoretin and Podophyllotoxin
. Regarding their sources, Berbamine is extracted from Berberis vulgaris with a reported apoptosis in human myeloma cells (51), (52).