Next were pollen allergens
, air pollution/irritants, and animal allergens.
Localization, release and bioavailability of pollen allergens
: The influence of environmental factors.
The occurrence of sensitization to food, HDM and pollen allergens
was 38%, 80.25% and 53.50% respectively among the sample population.
Kopec et al., "Genetic engineering of the major timothy grass pollen allergen
, Phl p 6, to reduce allergenic activity and preserve immunogenicity," Journal of Immunology, vol.
We used the same standardized extract of five grass pollen allergens
as for the skin test (Stallergenes Laboratory) The initial allergen concentration of standardized pollen extract was 0.1 or 0.2 IR (index of reactivity), as previously described by Aubier et al.
Researchers now believe that most food allergies are acquired due to cross-reactivity with pollen allergens
. Consequently, people who have pollen allergies might develop many plant food allergies--even to new foods that they've never eaten before.
Identification of canary grass (Phalaris aquatic) pollen allergens
by immunoblotting: IgE and IgG antibody binding sites; Allergy 1993; 48: 273-281
However, no association of HLA-DRB1*12 was reported in asthma patients in the Venezuelan population and sensitization to pollen allergens
like birch pollen (Juhlin et al., 1969; Sparholt et al., 1994).
Sensitization to mite, microbial, and pollen allergens
was detected with an ImmunoCAP[R] technology based on immunofluorescence when allergens are sorbed on a 3D cellulose sponge that increases a specific antigen-binding surface.
Like Oralair, Grastek (Timothy Grass Pollen Allergen
Extract) has a black box warning of the potential for severe allergic reactions such as anaphylaxis.
It has been evaluated from the crystal structure of this birch pollen allergen
in complex with the Fab fragment of a murine monoclonal IgG antibody (BV16), that the centrally located residue Glu45 is critical for antibody recognition and forms two hydrogen bonds with the heavy-chain variable region of the Fab fragment .
Blatt et al., "Mapping of conformational IgE epitopes with peptide-specific monoclonal antibodies reveals simultaneous binding of different IgE antibodies to a surface patch on the major birch pollen allergen
, Bet v1," Journal of Immunology, vol.