Its transcriptional cassette merges multi-factorial modifications to the liver-specific promoter module, FVIII transgene, synthetic polyadenylation
signal and vector backbone sequence.
signal (AATAAA) was present 14 nucleotides upstream of the poly(A) tail in both PTGES2a and PTGES2b genes (NCBI accession number: KY132103 and KY132104).
Comparative analysis of protein synthesis, transcription and cytoplasmic polyadenylation
of mRNA during maturation of bovine oocytes in vitro.
Detection of polyadenylation
signals in human DNA sequences.
For the protection of the 3' end against degradation by exonucleases and the export of mature mRNA to the cytoplasmic environment, nuclear polyadenylation
is a crucial step (17).
The results of TopHat included all alternative splicing information, which was classified as skipped exon (SE), alternative 5' splicing site, alternative 3' splicing site, retained intron (RI), mutually exclusive exon, alternative promoter, alternative polyadenylation
. The results are shown in Figure 1b.
Several additional DNA sequences flanking the 4qter-DRs are essential for disease development, including the simple sequence length polymorphism proximal to D4Z4 and the distal polyadenylation
signal (PAS, ATTAAA) for the DUX4 transcript., Present pathogenic models were proposed to correlate with chromatin relaxation on D4Z4 contraction.
Structurally, the avian [mu]-opioid receptor messenger RNA (mRNA) species were complex, displaying differential splicing, alternative stop codons, and multiple polyadenylation
Others are involved in important processes at the RNA level, including ribosome binding, mRNA processing (splicing, editing, polyadenylation
) and transcription termination.
Notably, no conserved polyadenylation
signal similar to bamboo mosaic virus and PVX was detected in the 3' UTR of AltMV .