Among them, y was traits observation value vector, u was random residual polygenic
effect value vector, its mean value was 0.
BEST participants do not have DMA% data and were only involved in the polygenic
scoring analyses; thus, these participants are not included in Table 1.
It is likely that for a given polygenic
condition there might be other population-specific genetic determinants.
This makes it possible to measure polygenic
score, but it is still unclear whether there is sufficient difference on a gene by gene basis to accurately determine risk at the individual level.
In contrast to monogenic disorders, where results from single mutations lead to predictable phenotypes, the complex genetic architecture of susceptible and protective alleles in polygenic
type 2 diabetes is more difficult to discern.
As common risk variant NCAN gene has small effect size in polygenic
model of schizophrenia unable to reach statistical significance in some association studies.
Through insightful discussions of Vico's prismatic interpretations of the Italian language and identity, from a polygenic
explanation to a more homogeneous characterization that surfaces in the final revision of the Scienza nuova (1744), Gambarota contends that Vico's attempt to create a foundational myth for modern Italy in order to overcome cultural and political disintegration is imbued with the cognitive power of his ingenium, in which talent, memory and imagination constitute "the founding triad of invention" (101).
inheritance refers to conditions determined exclusively by a large number of genes, each with a small effect, acting addictively (i.e.
Information on the quantum of induced polygenic
variability or micromutations and the genetic parameters for different polygenic
traits in segregating generations of mutagenized populations gives an indication about the scope of improvement in these traits through selection (Sheeba et al., 2003).
The initial part deals with the genetic basis of obesity delving into monogenic causes involving leptin, POMC, MC4R, etc., as well as polygenic
The most relevant current hypotheses, which need to be confirmed, establish that the cause of autism is a genetic alteration, with polygenic
Hematologic, monogenic, and polygenic
causes of stroke are examined, and risk factors such as oral contraceptives, migraine, and drug abuse are examined.