Clinical and therapeutic features of polymorphous low-grade adenocarcinoma. Oral Surg Oral Med Oral Pathol 1994;77:41-7.
Polymorphous low-grade adenocarcinoma of minor salivary gland.
Polymorphous low-grade adenocarcinoma is a low-grade malignant epithelial carcinoma almost exclusively arising in minor salivary glands with bland cytologic features.
Bahrami et al (96) studied PLAG1 expression by immunostaining and PLAG1 gene rearrangement by fluorescence in situ hybridization (FISH) in 22 carcinoma ex pleomorphic adenomas along with 39 cases representing various benign and malignant salivary gland neoplasms: adenocarcinomas, not otherwise specified (4 cases); mucoepidermoid carcinomas (8 cases); adenoid cystic carcinomas (7 cases); salivary duct carcinomas (4 cases); epithelial-myoepithelial carcinomas (2 cases); polymorphous low-grade adenocarcinoma (1 case); myoepithelial carcinoma (1 case); adenoid cystic carcinoma (1 case); basaloid carcinoma (1 case); pleomorphic adenomas (5 cases); basal cell adenomas (4 cases); and low-grade salivary gland neoplasm, not otherwise specified (1 case).
Polymorphous low-grade adenocarcinoma (PLGA) is a malignant neoplasm that occurs almost exclusively in the minor salivary glands, especially those in the palate.' This tumor is of particular interest because of its low degree of aggressiveness, its slow growth, and its conspicuous architectural polymorphism--features that for many years have complicated its recognition as a tumor type distinct from other adenocarcinomas.
The term polymorphous low-grade adenocarcinoma was first used in 1984 by Evans and Batsakis to describe a tumor of the salivary glands that had as its primary histologic characteristic a variety of architectural patterns associated with cytologic uniformity.
Cytogenetic similarities between two types of salivary gland carcinomas: adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma
. Cancer Genet Cytogenet.
Polymorphous low-grade adenocarcinoma (PLGA) is a malignant neoplasm that almost always arises in the minor salivary glands.
The following year, Evans and Batsakis used the term polymorphous low-grade adenocarcinoma to describe this malignancy as a clinically and pathologically discrete entity.
(3) The neoplastic cells in polymorphous low-grade adenocarcinoma
grow in a combination of two or more of these five basic architectural patterns: (1) tubules and ductlike structures, (2) cords and trabeculae, (3) solid nests, (4) cribriform pattern with pseudoluminal spaces, and (5) papillae.
Polymorphous low-grade adenocarcinoma
of minor salivary glands: a study of 14 cases of a distinctive neoplasm.