polymyxin


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polymyxin

[‚päl·i′mik·sən]
(microbiology)
Any of the basic polypeptide antibiotics produced by certain strains of Bacillus polymyxa.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The growing epidemic of infections in the ICU caused by MDR pathogens has led clinicians to reconsider prescribing pPB and colistin (polymyxin E) drugs that were removed from use in the past because of their neuro-and nephro-toxicity.17 An earlier study evaluated the efficacy of PB in MDR pathogens when there is very narrow choice.18 In case of A.
Polymyxin B induced nephropathy was defined as the doubling of serum creatinine to a value [greater than or equal to] 2.0 mg/dl (34-35).
Patients who received polymyxin B treatment were selected from the hospital database and information on basic characteristics, laboratory results, therapeutic options, and outcomes was abstracted.
The commonest pathogen in our study, Pseudomonas aeruginosa, was resistant to the commonly used beta-lactam antibiotics, with more than 66% (30) isolates resistant to all generations of cephalosporin, while 33% isolates being sensitive only to cefipime and 44.4% isolates were sensitive to polymyxins. All 34 (100%) isolates of S.
While very effective, polymyxins are relegated to a last-resort option due to the high incidence of kidney toxicity (nephrotoxicity), with rates up to 60% for the polymyxin therapy.
coli and also differentiate the chromosome- and plasmid-encoded resistance in 15 minutes, and should be evaluated on other species for which phosphoethanolamine addition is involved in polymyxin resistance.
During 2013–2014, polymyxins (including polymyxin B and colistin) exhibited prominent in vitro activity against E.
Antibacterial action of polymyxin can be segregated in two parts.
As of July 11, treatment was switched to the triple combination of meropenem (1 g IV TID), tigecycline (50 mg IV BID, after a 100 mg loading dose), and polymyxin B (500,000 units IV BID).
At this time, CDC recommends that Enterobacteriaceae isolates with a colistin or polymyxin B MIC >4 ftg/ml be tested for the presence of mcr-1; testing is available through CDC (5).