polypeptide


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Related to polypeptide: Polypeptide chain

polypeptide:

see peptidepeptide,
organic compound composed of amino acids linked together chemically by peptide bonds. The peptide bond always involves a single covalent link between the α-carboxyl (oxygen-bearing carbon) of one amino acid and the amino nitrogen of a second amino acid.
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Polypeptide

 

an organic compound containing six to 80–90 amino acid residues; the upper limit corresponds to a molecular weight of about 10,000. Such polypeptides, unlike proteins, can pass through semipermeable membranes.

The simple polypeptides are crystalline substances that are readily soluble in water and have chemical properties similar to those of amino acids. The complex polypeptides are amorphous and react with water to yield colloidal solutions. Polypeptides are formed in the organism during enzymatic proteolysis (autolysis of tissue, digestion, and so on) and during biosynthesis from amino acids. Many natural polypeptides exhibit the biological activity of hormones, antibiotics, and toxins. Synthetic polypeptides serve as models in studying the structure and biological activity of proteins.

polypeptide

[¦päl·i′pep‚tīd]
(biochemistry)
A chain of amino acids linked together by peptide bonds but with a lower molecular weight than a protein; obtained by synthesis, or by partial hydrolysis of protein.
References in periodicals archive ?
Chapter Four Polypeptide Drug Production by Regions by Technology by Applications
Remind students that the P Site is the site where the growing polypeptide chain is made.
Chapter Two Synthesis Polypeptide Drug International and China Market Analysis
Although the degree of sequence diversity between subtypes is great, particularly in the HA1 polypeptides (34%-59% homology between subtypes), more conserved regions are found in HA2 (51%-80% homology between subtypes).
We found that the Brazil nut protein contained one major epitope in the light-chain and at least three more prominent response regions in the heavy-chain polypeptide sequences comprising a total of 127 amino acids.
On one hand, the indications of polypeptide drugs are in wide range and the curative effects are obvious, mainly for the application of tumor, metabolism, cardiovascular diseases, infectious diseases, etc.
Table of Contents for the report "2012 Deep Research Report on Global and China Synthesis Polypeptide Drug Industry" cover:
The identity of this polypeptide was demonstrated by N-terminal amino acid sequencing analysis and by immunodetection assays using antibodies raised against the purified flagellin.
Louis, MO, USA) and polypeptide analyses and immunodetection assays were conducted as described for insect cells (4,57).
According to historical data, the approval ratio of polypeptide drugs in clinical research is 23 % to 26 %.
During various physiological processes such as protein synthesis, degradation and transport through membranes, they bind to interactive sites of polypeptides thereby preventing their improper interaction with other molecules and enabling controlled further processing of the polypeptide in question.
com Database Global and China Synthesis Polypeptide Drug Industry 2012 Deep Research Report