Alpers, "Maternal immunization with pneumococcal polysaccharide vaccine
in the highlands of Papua New Guinea," Vaccine, vol.
The Advisory Committee on Immunization Practices (ACIP) currently recommends that both 13-valent pneumococcal conjugate vaccine (PCV13) and 23-valent pneumococcal polysaccharide vaccine
(PPSV23) be given to all immuno-competent adults aged >65 years.
The other is a killed vaccine (Vi capsular polysaccharide vaccine
[ViCPS]), given intramuscularly in a single dose (table).
Infants and toddlers received MCC vaccine, and persons 2-19 years of age received meningococcal A/C polysaccharide vaccine
. In the months following the vaccination campaign, no more MenC cases were reported, and the outbreak was considered controlled.
It took half a century for polysaccharide vaccine
research to be revived; among the first success stories was a pneumococcal vaccine developed for adults, partially based on structural work by Monteiro's mentor, the late Malcolm Perry of the NRC.
Menomune (Meningococcal Polysaccharide Vaccine
, Groups A, C, Y, and W-135 Combined) is the brand name for Sanofi's tetravalent polysaccharide vaccine
sold in the US and Australia to protect against four N.
Experts recommend that adults 65 and older receive the pneumococcal polysaccharide vaccine
to help prevent meningitis.
The currently available pneumococcal polysaccharide vaccine
, is manufactured by both Merck (Pneumovax 23) and Lederie Laboratories (Pnu-Immune 23), and includes 23 purified capsular polysaccharide antigens (serotypes 1 ,2,3,4,5,6B,7F,8,9N,9V,10A,11A,12F,14 , 15B,17F,18C,19A,19F,20,22F,23F and 33F).
A single dose is required every year for seasonal influenza while a single dose of the pneumococcal polysaccharide vaccine
is needed every five years.
About PCV and PPV: PPV: Pneumococcal polysaccharide vaccine
(PPV), is a vaccine used to prevent Streptococcus pneumoniae (pneumococcus) infections such as pneumonia and septicaemia.
"The one-time polysaccharide vaccine
(PPV) shot, which is recommended for those age 65 and older, is also worth considering," says Dr.
The Phase 11 study evaluated the immune response and safety of Hib-MenCY-TT compared to a licensed monovalent Hib conjugate vaccine (ActHib[R] Haemophilus influenza type b Conjugate Vaccine Tetanus Toxoid Conjugate) in infants and to a licensed polysaccharide meningococcal ACWY vaccine (Menomune[R] Meningococcal Polysaccharide Vaccine
, Serogroups A, C, Y and W-135 Combined) in children 3-5 years of age.