Topsalysin (PRX302), an innovative, "First-in-Class" transmembrane pore-forming protein
, was genetically modified to be activated only by enzymatically-active PSA, which is produced in large quantities within the prostate of men with prostate cancer.
(NASDAQ: SPHS), which is studying topsalysin (PRX302), a first-in-class, pore-forming protein
, in late-stage clinical trials for the treatment of patients with urological diseases, has announced the conclusion of the ongoing investigation into the previously reported death of a patient in the company's Phase 2b trial for the treatment of localized prostate cancer is unlikely to be related to either topsalysin or the procedure.
toxins: from structure to function.
Stochastic sensing of organic analytes by a pore-forming protein
containing a molecular adapter.
Feil, "Pore-forming protein
toxins: from structure to function," Progress in Biophysics and Molecular Biology, vol.
Bayley, "A photogenerated pore-forming protein
," Chemistry and Biology, vol.
Although not considered a module, the central portion of each protein (~ 40 kDa) is designated MACPF to emphasize its conservation among the MAC proteins and its sequence similarity to perforin, a 70 kDa pore-forming protein
released from secretory granules of cytotoxic T lymphocytes.
Purification and characterization of a pore-forming protein
from the marine sponge Tethya lyncurium.
Both STIM1 and a plasma membrane pore-forming protein
known as Orai1 have recently been identified as essential components of the so-called the calcium release activated calcium (CRAC) channel.
Ostreolysin a pore-forming protein
from the oyster mushroom, interacts specifically with membrane cholesterol-rich lipid domains.
In theory, cells bathed in the pore-forming protein
, then exposed to a specific wavelength of light might open themselves up just long enough to admit a drug before shutting back down.
Scientists from Kunming Institute of Zoology under Chinese Academy of Sciences have found that the pore-forming proteins
in the skin of Bombina maxima, a species of toad in southwest China, have the function of inducing tissue repair and promoting scar-free healing of wounds.