pore-forming protein

pore-forming protein

[′pȯr ‚fȯrm·iŋ ‚prō‚tēn]
(immunology)
perforin
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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References in periodicals archive ?
Topsalysin (PRX302), an innovative, "First-in-Class" transmembrane pore-forming protein, was genetically modified to be activated only by enzymatically-active PSA, which is produced in large quantities within the prostate of men with prostate cancer.
Sophiris Bio provides update of Phase 2b localised prostate cancer trial
(NASDAQ: SPHS), which is studying topsalysin (PRX302), a first-in-class, pore-forming protein, in late-stage clinical trials for the treatment of patients with urological diseases, has announced the conclusion of the ongoing investigation into the previously reported death of a patient in the company's Phase 2b trial for the treatment of localized prostate cancer is unlikely to be related to either topsalysin or the procedure.
Sophiris Bio Updates on Phase 2b Localized Prostate Cancer Trial Following Patient Death
Pore-forming protein toxins: from structure to function.
Mosquitocidal Activity of cyt Positive Bacillus thuringiensis Isolated from Soil Samples
Stochastic sensing of organic analytes by a pore-forming protein containing a molecular adapter.
Nanopore sequencing: from imagination to reality
Feil, "Pore-forming protein toxins: from structure to function," Progress in Biophysics and Molecular Biology, vol.
Role of pore-forming toxins in neonatal sepsis
Bayley, "A photogenerated pore-forming protein," Chemistry and Biology, vol.
Cationic polymers inhibit the conductance of lysenin channels
Although not considered a module, the central portion of each protein (~ 40 kDa) is designated MACPF to emphasize its conservation among the MAC proteins and its sequence similarity to perforin, a 70 kDa pore-forming protein released from secretory granules of cytotoxic T lymphocytes.
Human complement protein C8: the "Hole" story
Purification and characterization of a pore-forming protein from the marine sponge Tethya lyncurium.
First report of an anti-tumor, anti-fungal, anti-yeast and anti-bacterial hemolysin from Albizia lebbeck seeds
Both STIM1 and a plasma membrane pore-forming protein known as Orai1 have recently been identified as essential components of the so-called the calcium release activated calcium (CRAC) channel.
Shifts in body temperature activate immune response
Ostreolysin a pore-forming protein from the oyster mushroom, interacts specifically with membrane cholesterol-rich lipid domains.
Nebrodeolysin, a novel hemolytic protein from mushroom Pleurotus nebrodensis with apoptosis-inducing and anti-HIV-1 effects
In theory, cells bathed in the pore-forming protein, then exposed to a specific wavelength of light might open themselves up just long enough to admit a drug before shutting back down.
Controlling life's gateway; opening and closing cell membranes on demand
Scientists from Kunming Institute of Zoology under Chinese Academy of Sciences have found that the pore-forming proteins in the skin of Bombina maxima, a species of toad in southwest China, have the function of inducing tissue repair and promoting scar-free healing of wounds.
Substance in toad skin could help scarless healing

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