Positive modulation of NMDA receptors may have potential in the treatment of a range of neurological disorders associated with a range of cognitive, neurological and behavioral symptoms.
Positive modulation of NMDA receptors may have potential in the treatment of conditions associated with NMDA hypofunction and disorders associated with a high prevalence of anti-NMDA antibodies, such as anti-NMDA receptor encephalitis, as well as in disorders associated with reductions in plasma cerebrosterol, such as Huntington's disease and Alzheimer's disease.
This component presented a pattern of positive modulation during aversive emotional processing; the corresponding network included frontal, limbic, occipital, temporal, and cerebellar regions, so it was named "cerebellar-medial-frontal" (Table 2, Figures 4 and 5).
Results obtained from comparing neutral and fear conditions showed a positive modulation in a network predominantly cerebellar-medial-frontal, which also included activations in temporal regions.
This evidence in resting state, together with the results of positive modulation and cerebellar functional connectivity within IC4 of the present study, suggests that the cerebellum is involved in emotional processing.
IC4 had a positive modulation in the fear condition while IC2 presented a negative modulation to facial stimuli), the coefficients of temporal correlation between the onsets of fear and the time courses of these two components were reviewed.