posttranslational modification


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posttranslational modification

[‚pōs·tranz¦lā·shən·əl ‚mäd·ə·fə′kā·shən]
(cell and molecular biology)
Any polypeptide alteration that occurs after synthesis of the chain.
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References in periodicals archive ?
sup][23],[24]As TGF-[sz]R and PDGF receptors (PDGFR) are both glycosylated, and CF is their common posttranslational modification,[sup][25] we believed that blocking CF may simultaneously inhibit TGF-[sz] and PDGF signaling pathways, resulting in a synergistic protective effect in ameliorating EMT.
S-Nitrosylation of cysteine residues as posttranslational modification influence cardiac function includes receptors, enzymes, ion channels, transcription factors, and structural proteins [116].
Phosphorylation is the best understood posttranslational modification.
This discovery of posttranslational modifications in the proximal part of the neuron represents a major paradigm shift, said Bhattacharya.
In a similar manner, S-sulfhydration is a posttranslational modification of specific residues, through the formation of persulfide (-SSH) bonds.
2006, Posttranslational modification of proteins: Expanding nature's inventory.
According to Professor Steven Gygi of Harvard Medical School, 2DE/MS is "best suited to studying posttranslational modification.
Additional in vitro and murine studies confirmed that this variant led to loss-of-function of the SRBI protein, likely via impaired posttranslational modification.
Mitochondrial ROS/RNS Induce Posttranslational Modification of ATP Synthase Residues
Objective: Cellular processes are largely governed by sophisticated protein posttranslational modification (PTM)-dependent signaling networks, and a systematic understanding of regulatory PTM-based networks is a key goal in modern biology.
Osteocalcin (OC), a vitamin K-dependent protein expressed by osteoblasts, contains 3 gamma-carboxyglutamic acid residues derived from the vitamin K-dependent posttranslational modification of glutamic acid residues.

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