posttranslational modification


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posttranslational modification

[‚pōs·tranz¦lā·shən·əl ‚mäd·ə·fə′kā·shən]
(cell and molecular biology)
Any polypeptide alteration that occurs after synthesis of the chain.
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As a result, the most desirable readout of the human genome is not an individual's genome itself, but instead it is the expression of the genome into proteins, the cellular localization of those proteins, and the posttranslational modifications of those proteins.
Among the epigenome which is defined by DNA methylation patterns and the associated posttranslational modifications of histories and non histone proteins is the key regulatory circuit (2).
To fulfill this demand, more advanced studies will be needed, taking advantage of the biophysics and understanding of posttranslational modifications that mandate protein folding and the ultimate form of the three-dimensional structures.
4] Nonstandard abbreviations: PTMDPs, nonenzymatic posttranslational modifications derived products; Hb [A.
Possible posttranslational modification of N-terminal proANP fragments should be investigated.
This applies for the nonenzymatic posttranslational modifications, which alter structural and biological properties of proteins in living organisms.
It is not known if similar posttranslational modifications exist in pro-ANP and pro-CNP.
Regulation of sirtuin function by posttranslational modifications.
While small molecules exist in single molecular compositions, even pure preparations of biopharmaceuticals contain multiple forms with different forms of the protein such as slightly different folding and different and multiple posttranslational modifications.
Despite many investigations dealing with genetics, proteomics, and posttranslational modifications, we still have not identified targets for improved treatment of these malignancies, and only a few biomarkers have been introduced as prognostic factors.
In fact, biologics are rarely, if ever, limited to a single defined entity; typically, biologics contain a range of discrete molecular entities, differing in posttranslational modifications or other minor structural features.
A speculation on the source of these antibodies suggests that posttranslational modifications (glycosylation and phosphorylation) of some proteins may create neo-epitopes for the production of autoantibodies (14, 15).

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