potentiator


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potentiator

[pə′ten·chē‚ād·ər]
(food engineering)
(pharmacology)
A drug that augments the response of a second drug so that the total response is greater than the predictible additive effect.
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References in periodicals archive ?
Target: PF-0495824, an AMPA receptor potentiator for cognitive impairment associated with schizophrenia
Food and Drug Administration for PTI-808, a CFTR potentiator, is now active and that the Company has initiated a Phase 1 study in healthy volunteers.
The Potentiator program works by disrupting the outer cell membrane of gram-negative bacteria, which is what presents a persistent barrier for many antibiotics.
4-Hydroxy Isoleucine: A novel amino acid potentiator of insulin secretion.
ACFTR potentiator in patients with cystic fibrosis and the G551D mutation.
The other major event is the anticipated Food and Drug Administration approval of a fixed-dose combination of ivacaftor and lumacaftor, a combined potentiator and corrector of the CF transmembrane conductance regulator (CFTR).
4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion.
BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activity.
Ivacaftor, known as a CFTR potentiator, keeps the CFTR protein channels on the cell surface open longer to increase the flow of salt and water into and out of the cell.
Alcohol itself is a known potentiator of iron absorption (Olynyk 2005) though to what extent this relationship exists is unknown.
METHODS AND RESULTS: Golgi analysis of hippocampi from weanling rats confirmed that developmental exposure via the maternal diet to NDL PCB-95 (2,2',3,5'6-pentachlorobiphenyl), a potent RyR potentiator, phenocopies the dendrite-promoting effects of A1254.
The Vertex drug, taken orally twice a day, is a CFTR potentiator.