Genetically engineered poxviruses
for recombinant gene expression, vaccination, and safety.
"Our studies suggest that despite their transient nature, gene expansions may provide a potent means of adaptation in poxviruses
, allowing them to survive either immune or pharmacological challenges," Malik said.
The human zoonotic infections caused by poxviruses
are relatively rare.
are the largest animal viruses and can be visualized via light microscopy.
In addition to HDP-CDV, as many as 27 other drugs show promise against poxviruses
in early lab tests, says virologist Earl R.
Conversely, cats have been found to be susceptible to members of the genus Parapoxvirus, raccoonpox virus, and uncharacterized poxviruses
Because of this common poxvirus morphology, it is difficult to discernbetween genera of poxviruses
when using techniques like histopathology and EM.
, such as smallpox, vaccinia virus and the Monkeypox virus, invade host cells and replicate, causing disease.
The next five chapters are devoted to understanding the diverse strategies used by clinically relevant human viruses to subvert host-interferon responses: herpes simplex virus, poxviruses
, hemorrhagic fever viruses, influenza virus, and hepatitis C virus.
3, 1999 SCIENCE, the biologists conclude that myxoma virus, and probably variola and other poxviruses
, somehow use the chemokine receptors to gain entry to cells.
Under the expanded agreement, the Institute will use the company's XenoMouse technology to make fully human monoclonal antibodies that will be tested for their ability to provide protection against viral infections attributed to poxviruses
, including smallpox, pose a potential biological warfare or bioterrorism threat to United States interests.
The increasing use of molecular methods has resulted in the identification of several novel poxviruses
from humans and animals, many of which probably represent new genera (2-9); often, the reported host range of these viruses is limited to the species of the index case.