pregnenolone


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pregnenolone

[preg′nen·ə‚lōn]
(biochemistry)
C21H32O2 A steroid ketone that is formed as an oxidation product of cholesterol, stigmasterol, and certain other steroids.
References in periodicals archive ?
Recent tests show that people with Alzheimer's disease given oral doses of pregnenolone, which the body converts to pregnenolone sulfate, experience no memory improvement, says Roberts.
Rat memory skills boosted by steroid
0375 mg twice-weekly; pregnenolone 20 mg at bedtime, and neonatal bovine adrenal cortex.
The clinical importance of 5-Alpha-Reductase in human health and pathology: part 2: women, polycystic ovarian syndrome, premenstrual dysphoric disorder, hormone replacement therapy, and beyond
P450scc converts cholesterol into pregnenolone, which is ultimately transferred to smooth endoplasmic reticulum, where the synthesis of testosterone takes place via the actions of 3[beta]-hydroxysteroid dehydrogenase (3[beta]-HSD), I7[alpha]-hydroxy/ [C.
Benzo[a]pyrene reduces testosterone production in rat leydig cells via a direct disturbance of testicular steroidogenic machinery
Longitudinal study of plasma pregnenolone and 17-hydroxypregnenolone in full-term and preterm neonates at birth and during the early neonatal period.
Development and performance evaluation of a tandem mass spectrometry assay for 4 adrenal steroids
Pregnenolone also is produced by the adrenal glands and is important in regulating the adaptive homeostat.
The neuroendocrine theory of aging: minimizing chronic stress to prevent the degenerative diseases of age
Only three major enzyme reactions may be needed for the conversion of pregnenolone or progesterone to the simplest steroid with CG activity.
Biosynthesis of endogenous cardiac glycosides by mammalian adrenocortical cells: three steps forward
It is made with ginkgo biloba, pregnenolone and phosphatidyl serine.
Science fuels boom in herbal products
estradiol, progesterone, pregnenolone, thyroid) and chelation to remove heavy metals are also used as needed.
Reversing cognitive decline
For example, increased OLF was reported in animals and/or culture models using ACTH (39,40); angiotensin II (41); combinations of ACTH, angiotensin II, aldosterone, and cortisol (42, 43); and progesterone and pregnenolone (44).
De novo biosynthesis and radiolabeling of mammalian digitalis-like factors
and/or adrenal shots of cortisol, DHEA, and pregnenolone with methyl B12 and folic acid (see my previous columns).
Anxiety, depression, and psychosis
Adult mate rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017[alpha] and P450 aromatase localized in neurons.
The environmental estrogen bisphenol A inhibits estradiol-induced hippocampal synaptogenesis
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