Oral leukoplakia is the most common premalignant
lesion in oral cavity and is associated with the development of oral cancer.
The role of oral HPV infection in malignant alteration of oral premalignant
disorders remains unclear.
As per this concept, a single cell is transformed and gives rise to one large, extended, premalignant
field by clonal expansion, and gradual replacement of normal mucosa by atypical ones.
6% presented with malignant conditions and 16% presented with premalignant
From the results of this study, it can be concluded that abnormal uterine bleeding occurring as heavy, frequent or acyclic flow in perimenopausal age is alarming and needs thorough evaluation with endometrial sampling as it could be the only clinical manifestation of endometrial hyperplasia which is a premalignant
lesion and precursor of endometrial cancer.
In the present study, maximum number of cases between 2140 years of age group showed highest incidence of abnormal colposcopic findings, this is in accordance with the view that dysplasias are premalignant
lesions and they precede malignancies by one decade.
There were 64 premalignant
and 23 malignant cases in our study.
Cervical SCC does not arise de novo but is preceded by premalignant
high grade squamous intraepithelial lesions (HSILs) that are composed of immortalized, clonal cell population that have not yet gained the potential to invade the underlying cervical stroma.
Scores "seemed lower" for premalignant
vulvar disease when compared with inflammatory, infectious, and other disease types, the investigators reported.
Most of these cases carry low risk of Cervical Intraepithelial Neoplasia Stage III (a premalignant
condition that is indicative of higher risk of cervical cancer), especially when not associated with HPV-positivity.
The results of a trial presented at the 2015 American Society of Clinical Oncology Meeting suggest that the intake of active compounds found in green tea could help protect against the development of prostate cancer among men with premalignant
Several chapters cover the specific application to benign, premalignant
, and malignant lesions, including considerations of patient selection for successful surgery and comparison to other options.