Premixed insulin can be co-prescribed with metformin, DPP4 inhibitors and alpha glucosidase, inhibitors.1
Premixed insulin and sulfonylurea should not be administered with the same meal.
Premixed insulin regimes target fasting, post prandial (post breakfast) and pre-dinner glucose values, while basal insulins target only fasting glycaemia.
This review article describes the pharmacology of premixed insulin, and covers recent advances in this field.
The invention of insulin analogues, specifically aspart and lispro, has allowed them to be combined with protaminated aspart and lispro, respectively.7 The favourable pharmacokinetic properties of these molecules has added flexibility, safety and convenience to premixed regimes.7 Premixed analogues have also been tried as once-daily and thrice-daily regimes; for initiation as well as for intensification.8 Such research has expanded the utility of these drugs, coupled with greater understanding of the benefits of insulin therapy.
Initiation With Premixed Insulin: Once Daily Various studies have explored the efficacy of premixed insulin as a treatment for insulin-naive patients.
Thanks to continued implementation of public construction projects, domestic premixed concrete market will show a rosy picture this year, encouraging domestic makers to expand production facility.
Taiwan Cement predicted Taiwan will see shipments of premixed concrete grow at least 12% year-on-year this year.
In addition, Goldsun will set up a few premixed concrete plants in central Taiwan with total investments reaching NT$150 million in 2011.
Goldsun will also establish several premixed concrete plants in China with annual investments reaching NT$90 million, and increase investments in China in the next few years if the market allows.