It has been reported that fenofibrate suppresses cardiac hypertrophy, fibrosis, and inflammation in pressure overloaded
rats [12-16,31,32], in agreement with our results that fenofibrate inhibited pressure overload-induced cardiac hypertrophy in rats subjected to AAC.
It illustrated that the ventricular remodeling model induced by pressure overload
Further analysis indicated that PDGFR-beta in heart muscle cells contributes to the protective response to pressure overload
by triggering the growth of new blood vessels, providing new insight into the physiologic functions of PDGFR-beta.
In summary, RV failure is the result of inadequate contractility, volume or pressure overload
. All of these mechanisms contribute to the progression of RV decompensation.
Thus, it cannot be excluded that, apart from hemodynamic and pressure overload
, some endocrine factors may also be implicated in physiological heart hypertrophy.
Because prone positioning (PP) has been shown to be a safe way to reduce airway pressure and to improve alveolar ventilation, we decided to assess its effect on right ventricular (RV) pressure overload
in ARDS patients.
One possible explanation for L-arginine's harmful effects is that instead of generating nitric oxide, it may actually produce reactive oxygen species that create pressure overload
. L-arginine also increases homocysteine production.
The 25 chapters overview strategies of conditional gene expression in myocardium, describe a method for studying endothelial progenitor cells in the regeneration of vascular endothelial cells, and present protocols for delineating and evaluating genes involved in cardiac hypertrophy in response to pressure overload
. Other topics include manipulation of neuronal nitric oxide synthase, examination of stem cells in post-ischemic and transplanted hearts, and detection of apoptosis in cardiovascular disease.
BNP is secreted primarily from the left ventricle in response to pressure overload
and regulates blood pressure, electrolyte balance and fluid volume.
For many lesser men the combination of sleep deprivation, the unpredictability of his profession and the expectation of supporters renowned for their wild optimism would equal pressure overload
. Not so for McCarthy.
BNP is synthesized in cardiac ventricular tissue, primarily in response to volume expansion and pressure overload
. Preeclampsia, which complicates 5% of pregnancies and causes considerable maternal and neonatal morbidity, is characterized by markedly increased peripheral vascular resistance, which leads to increasing blood pressure, in turn causing pressure overload
in the already volume-overloaded hemodynamic state of pregnancy.
In recent years an increase in the number of failures of hydraulic components caused by pressure overload
have been reported.