lidocaine

(redirected from prilocaine)
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Related to prilocaine: Prilocaine hydrochloride, Articaine

lidocaine

[′līd·ə‚kān]
(organic chemistry)
C14H22N2O A crystalline compound, used as a local anesthetic. Also known as lignocaine.
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We did not find a previous report of spinal myoclonus associated with prilocaine.
When using prilocaine or mepivacaine as local anesthetic drug a complete surgical analgesia of 30 to 45 min can be achieved.
Plasma levels of lidocaine and prilocaine were less than 2% of the levels considered toxic, and the metabolite o-toluidine was undetectable in all infants.
Effects of the addition of potassium to prilocaine or bupivacaine: a double blind comparative study.
Methaemoglobinaemia secondary to topical lignocaine/ prilocaine in a circumcised neonate.
The European Phase III study, one of two major international trials, was designed to determine whether PSD502, a metered-dose aerosol formulation of lidocaine and prilocaine, would result in longer intravaginal ejaculatory latency time (IELT) in men who suffer from PE.
We could not find a satisfactory explanation for the pain experienced by them on injection of lignocaine, although pain on injection of local anaesthetic solution in IVRA has been reported previously with prilocaine and chloroprocaine 11,12) and alkalinisation of the solution has been found to be effective in reducing the pain of injection of prilocaine (11).
Fougera has also been given clearance for lidocaine and prilocaine cream 2.
Topical prilocaine and/or lidocaine have been proposed for neonatal circumcision, but satisfactory results are not predicted due to mixed results when used for analgesia in other pediatric procedures, the side effect of methemoglobinemia, and the need for application an hour or more prior to circumcision (Frayling, Addison, Chattergee, & Meakin 1990).
Finally, future clinical trials should compare DPNB with newly proposed anesthetic techniques, such as direct local infiltration of the foreskin,(25) oral sucrose,(26) and topical anesthesia with newer preparations such as 30% lidocaine cream(27) or a eutectic mixture of the local anesthetics lidocaine and prilocaine (EMLA).
Fougera'sjust-approved lidocaine/ prilocaine cream (a generic version of AstraZeneca's EMLA) is an important product that has been unavailable for several months, he notes.
Acquired methaemoglobinaemia is usually caused by oxidizing drugs and toxic agents such as methylene blue, prilocaine, sulphonamides, and nitrates (7).