proaccelerin


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Related to proaccelerin: labile factor

proaccelerin

[¦prō·ak′sel·ə·rən]
(biochemistry)
A labile procoagulant in normal plasma but deficient in the blood of patients with parahemophilia; essential for rapid conversion of prothrombin to thrombin. Also known as factor V; labile factor.
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[4] Human genes: CYBB, cytochrome b-245, beta peptide; BRCA1, breast cancer 1, early onset; CFTR, cystic fibrosis transmembrane conductance regulator (ATP binding cassette sub-family C, member 7); BRCA2, breast cancer 2, early onset; ACADM, acyl-CoA dehydrogenase, C-4 to C-12 straight chain; CYP2C9, cyto chrome P450, family 2, subfamily C, polypeptide 9; VKORC1, vitamin K epoxide reductase complex, subunit 1; F2, coagulation factor II (thrombin); F5, coagulation factor V (proaccelerin, labile factor); MTHFR, methylenetetrahydrofolate reductase (NAD(P)H).
In the present study, we demonstrate the genotyping accuracy of a quadruplex high-resolution amplicon-melting assay for mutations in F55 [coagulation factor V (proaccelerin, labile factor)] (1691G>A), F2 [coagulation factor II (thrombin)] (20210G>A), and MTHFR (1298A>C and 677C>T) genes.
[5] Human genes: F5, coagulation factor V (proaccelerin, labile factor); MTHFR, 5,10-methylenetetrahydrofolate reductase (NADPH); F2, coagulation factor II (thrombin); LCT, lactase.