procoagulant


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procoagulant

[¦prō·kō′ag·yə·lənt]
(biochemistry)
Any of blood clotting factors V to VIII; accelerates the conversion of prothrombin to thrombin in the presence of thromboplastin and calcium.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Furthermore, all markers for vasculitis and procoagulant factors were negative, homocysteine levels were normal, MRA examination were normal.
Hooper and colleagues postulated that tumor necrosis factor (TNF)-downregulation of protein S may be a mechanism for local and procoagulant activity and thrombosis in patients with HIV/AIDS [20].
Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: Implications for coagulation events and antigenic spread in systemic lupus erythematosus.
Viral-induced endothelial injury causes increased levels of von Willebrand factor, total antigenic protein S, plasminogen activator inhibitor (PAI-1), endothelial-derived thrombomodulin and other procoagulant products of endothelial cell activation.
These scientists also found that melatonin attenuates the stress-induced procoagulant response to acute psychosocial stress, a potent trigger of acute coronary disease, in the same group of healthy men.
Thrombosis is the most easily recognized manifestation of APS and the manifestation that is most easily explained by a mechanism: endothelial activation or injury leading to local activation of adhesion molecules and procoagulant proteins, leading to in situ and potentially embolic thrombus.
The mechanism by which trauma might initiate CAPS remains uncertain, but may involve cytokine production affecting endothelial cell function and the upregulation of procoagulant molecules (Immunobiology 2005;210:727-33).
This results in the release of cytokines with vasoactive and procoagulant properties (interleukins, tumor necrosis factor, platelet-activating factor, and urokinase) (17,18).
The subsequent loss of normal endothelial homeostatic properties would eventually lead to a "proinflammatory, proadhesive, and procoagulant endothelial surface that is not yet present in our cohort.
The company's primary product is the Duett(TM) sealing device which combines an easy-to-use balloon catheter delivery mechanism with a biological procoagulant mixture to enable cardiologists and radiologists to rapidly seal the puncture site following catheterization procedures such as angiography, angioplasty and stenting.