Furthermore, all markers for vasculitis and procoagulant
factors were negative, homocysteine levels were normal, MRA examination were normal.
Hooper and colleagues postulated that tumor necrosis factor (TNF)-downregulation of protein S may be a mechanism for local and procoagulant
activity and thrombosis in patients with HIV/AIDS .
Surface blebs on apoptotic cells are sites of enhanced procoagulant
activity: Implications for coagulation events and antigenic spread in systemic lupus erythematosus.
Viral-induced endothelial injury causes increased levels of von Willebrand factor, total antigenic protein S, plasminogen activator inhibitor (PAI-1), endothelial-derived thrombomodulin and other procoagulant
products of endothelial cell activation.
These scientists also found that melatonin attenuates the stress-induced procoagulant
response to acute psychosocial stress, a potent trigger of acute coronary disease, in the same group of healthy men.
Thrombosis is the most easily recognized manifestation of APS and the manifestation that is most easily explained by a mechanism: endothelial activation or injury leading to local activation of adhesion molecules and procoagulant
proteins, leading to in situ and potentially embolic thrombus.
The mechanism by which trauma might initiate CAPS remains uncertain, but may involve cytokine production affecting endothelial cell function and the upregulation of procoagulant
molecules (Immunobiology 2005;210:727-33).
This results in the release of cytokines with vasoactive and procoagulant
properties (interleukins, tumor necrosis factor, platelet-activating factor, and urokinase) (17,18).
The subsequent loss of normal endothelial homeostatic properties would eventually lead to a "proinflammatory, proadhesive, and procoagulant
endothelial surface that is not yet present in our cohort.
The company's primary product is the Duett(TM) sealing device which combines an easy-to-use balloon catheter delivery mechanism with a biological procoagulant
mixture to enable cardiologists and radiologists to rapidly seal the puncture site following catheterization procedures such as angiography, angioplasty and stenting.