procoagulant

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procoagulant

[¦prō·kō′ag·yə·lənt]
(biochemistry)
Any of blood clotting factors V to VIII; accelerates the conversion of prothrombin to thrombin in the presence of thromboplastin and calcium.
References in periodicals archive ?
Hence, there is a decrease in both procoagulant and anticoagulant proteins.
5] The most significant hematological changes are physiologic anemia, neutrophilia, mild thrombocytopenia, increased procoagulant factors, and diminished fibrinolysis.
The first, represented by the procoagulant factors, is triggered by tissue factor (TF), (3) a cellular receptor in damaged tissues that forms a complex with activated factor VII (FVIIa) at the site of injury (Fig.
The PT and aPTT are therefore responsive to thrombin generated as a function of procoagulants, but much less responsive to thrombin inhibition by the natural anticoagulants, especially Protein C.
It is likely that a combination of factors is responsible for tilting the scale in favour of the procoagulant state in individuals infected by HIV.
Procoagulants have been found in brain tumors and a release of thromboplastin from degenerating neural tissue has been observed.
Anticancer drugs can provoke the release of procoagulants and cytokines from damaged tumor cells and direct alterations on vascular endothelium.
Thrombin generation in TF-activated plasma requires the presence of procoagulant phospholipid membranes for the assembly of thrombin-generating enzyme complexes (17).
The latter destroys the elevated promyelocyte population, causing the promyelocytes to release granules containing procoagulants.
The latter could be taken as an index of thrombin generation reflecting the overall balance of procoagulants and anticoagulants of plasma ex vivo.
Coagulation factors, or procoagulants, are activated sequentially, and a fibrin clot is formed, which slows and ultimately stops blood flow.
37) Factor Z is a vitamin K-dependent coagulation factor that acts in both a procoagulant and anticoagulant fashion in that it facilitates thrombin-phospholipid interactions, and it also indirectly inhibits factor Xa by interacting with plasma protein Z-dependent protease inhibitor (an inhibitor of factor Xa).