procollagen


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Related to procollagen: tropocollagen

procollagen

[prō′käl·ə·jən]
(biochemistry)
A high-molecular-weight form of collagen that is found in intracellular spaces and is believed to be the precursor of collagen.
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Meduri et al (65) investigated the relationship between procollagen types I and III, pulmonary and extrapulmonary organ dysfunction, and outcome during the natural course of ARDS and in response to prolonged methylprednisolone treatment.
9] The expression levels of Type I and III procollagen proteins were significantly lower in the POP group compared with the NPOP group, whereas the opposite was noted for the expression of Mfn2 , and the previous results were published in European Journal of Obstetrics, Gynecology, and Reproductive Biology in 2014.
Minneapolis, MN, USA), while ELISA kits for procollagen type I were purchased from Takara (Takara, Shiga, Japan).
Outside the cell, specific proteases called procollagen peptidases remove the extending propeptides, converting the procollagen molecules to collagen molecules.
A possible explanation for these observations is that IGF-I can stimulate the proliferation of fibroblasts and increases mRNA levels of procollagen type I [39].
In parallel with this, MHY498 treatment recovered the UVB-induced decrease in type 1 and type 3 procollagen protein levels in the skin (Figure 4(b)), indicating that the protective effect of collagen fiber by MHY498 is mediated at least partially through reducing MMP protein levels.
Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen a1(I) gene expression in human liver fat-storing cells.
Human fibroblasts cultured in serum-starved medium, consistently exhibited enhanced procollagen production when exposed to low level laser.
Current recommendation for the standardization of BTM measurements in future studies is to use serum carboxy terminal telopeptide of collagen type I (s-CTX) as the standard bone resorption marker and serum procollagen type I N-terminal propeptide (P1NP) as the standard bone formation marker [4].
The most informative ones for the monitoring of osteoporosis are procollagen I N-terminal extension peptide (P1NP) for assessing bone formation and C-telopeptide breakdown products (especially serum CTX and NTX) to assess bone resorption (5,8-10).
Interestingly, elevated levels of procollagen peptides detected early in ARDS is predictive of poor prognosis.
Serum concentration of carboxy-terminal propeptide of type I collagen and amino-terminal propeptides of type I procollagen is an objective measure of newly formed type I collagen.