procollagen


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Related to procollagen: tropocollagen

procollagen

[prō′käl·ə·jən]
(biochemistry)
A high-molecular-weight form of collagen that is found in intracellular spaces and is believed to be the precursor of collagen.
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At the 1-day time point, mature collagen fibers were observed in addition to more organized neoformation of procollagen and a marked decrease in inflammatory cells, (Fig 2B).
Ventricular fibrogenesis activity assessed by serum levels of procollagen type III N-terminal amino peptide during the staged Fontan procedure.
serum), procollagen type 1N-terminal propeptide (P1NP, serum), and other
[3] Nonstandard abbreviations: ALP, alkaline phosphatase; URL, upper reference limit; GGT, gamma-glutamyl transferase; P1NP, procollagen type 1 N-terminal propeptide; PEG, polyethylene glycol; PPA, PEG-precipitable activities.
Depleting [Gr-1.sup.+] myeloid cells in this manner markedly enhanced the extent of fibrosis as revealed upon analysis of trichrome-stained lung sections (Figure 2(b)) and transcript expression of procollagen 3 and fibronectin 1 (Figure 2(c)), both of which were significantly increased in the anti-Gr-1 mAb-treated mice when compared to the IgG-treated control group.
Although the majority of the studies mainly compared the quantitative and morphological changes of collagen fibers and/or detected the impact of collagenase upon collagen metabolism, the pathogenesis of POP in terms of the variations in the synthesis and secretion of procollagen in fibroblasts have not been explored.
P.05.6 High levels of osteoprotegerin and low levels of COOH-terminal propeptide of type I procollagen characterize the persisting bone derangement in celiac disease patients on long-term gluten-free diet.
Type I collagen could be assessed as biomarkers for the synthesis of the bone matrix by measuring N-terminal propeptides of type I procollagen (PINP) and carboxyterminally cross-linked telopeptides (CTX) [19].
In fact, IL-6, TNF[alpha], and type III procollagen are known to be elevated in the BAL and plasma of patients with ARDS, and their levels are known to undergo rapid, progressive, and significant decrease in those who experience clinical improvement following GC administration [10].
The patient's laboratory results were as follows: C reactive protein, 8.5mg/dL; white blood cell count, 8700/[micro]L; creatinine, 0.73 mg/dL; calcium, 9.7mg/dL; phosphate, 7.5 mg/dL (normal value: 2.9-4.9); total type I procollagen N-terminal propeptide, 605 [micro]g/L (normal value: 18.1-74.1); and tartrate-resistant acid phosphatase-5b, 6710mU/dL (normal value: 170-590).
BAP: bone alkaline phosphatase; CTX: cross-linked C-telopeptide of type I collagen; intOC: intact osteocalcin; N-mid OC: N-terminal/midregion osteocalcin; OPG: osteoprotegerin; PICP: C-terminal propeptide of type I procollagen; RANKL: receptor activator of nuclear factor kB ligand; V1: baseline; V5: visit 5; V6: visit 6.
Such inflammatory mediators will further induce collagen degradation by promoting apoptosis in dermal fibroblasts, enhancing the expression of the matrix metalloproteinases MMP-1, MMP3, and MMP-9, and preventing the expression of procollagen [15].