prodrug


Also found in: Dictionary, Medical, Wikipedia.

prodrug

[′prō‚drəg]
(physiology)
An inactive precursor of a drug that is activated via the body's metabolism.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
Mentioned in ?
References in periodicals archive ?
LPCN 1111, a novel oral prodrug of testosterone, originated and is being developed by Lipocine as a next-generation oral testosterone product with potential for once-daily dosing and is currently in Phase 2 testing.
Herein, the synthesis of a new potential Co(III) functional prodrug, trans-dichlorotetrakis(imidazole)cobalt(III) chloride (2) is presented utilizing a ligands substitution reaction from a known Co(III) starting material, trans-dichlorotetrakis(pyridine)cobalt(III) chloride (1) [31,32].
In the case of CD-NSC enzyme prodrug therapy, the apoptotic stimuli encountered upon administration into the tumor resection cavity are significant and unavoidable.
"We don't have to make the natural product, we can manipulate our chemical route to make the prodrug. We're hoping to make simple analogues that are as potent as thapsigargin or better, then work with others to get these to target certain cells."
Inspyr Therapeutics develops therapies for cancer using a novel technology platform that combines a powerful therapeutic (thapsigargin) with a patented prodrug delivery system that targets the release of drugs within solid tumors.
In light of the above and in continuation of our interest to synthesize a GI sparing NSAIDs prodrugs [2, 20], a new amide prodrug of naproxen (pro-NP) was synthesized and spectrally characterized and a validated stability-indicating RP-HPLC method was developed for studying the chemical stability of pro-NP.
Of the tested compounds, prodrug 1 demonstrated the highest activity towards human AChE ([IC.sub.50] = 0.89 [+ or -] 0.157 [micro]mol/mL); however, this activity is much lower than that of tacrine (2.77 * [10.sup.-4] [+ or -] 1.11 * [10.sub.-4] [micro]mol/ mL).
Phyton Biotech has achieved a major milestone in connection with the manufacture of thapsigargin, an inhibitor derived from the Thapsia plant that is the active agent for the investigational prodrug mipsagargin.
Introduction To decrease the ulcerogenic effects (by gastric lesions) of mefenamic acid, i.e., a non- steroidal anti-inflammatory drug (NSAID), it is desirable to design its prodrug [1-4] by converting its carboxylic acid into ester.
Their topics include discovering and developing isozyme-selected inhibitors involved in lipid metabolism, enzyme assays and rodent models of metabolic diseases, the evolution of an orally active prodrug of gencitabine, enzymatically activated phosphate and phosphonate prodrugs, and methods and principles of pancreatic function tests.
Captagon is a synthetic prodrug used as a stimulant R.Z.