prodrug


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prodrug

[′prō‚drəg]
(physiology)
An inactive precursor of a drug that is activated via the body's metabolism.
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Title: Efficient Liver Targeting and Uptake by Novel Tenofovir Prodrug, CMX157, for the Treatment of Hepatitis BDate: Tuesday, December 8, 2015Time: 6:10pm HSTLocation: Grand Wailea Hotel, Hawaii
About Ascendis Pharma A/S Ascendis Pharma is applying its innovative TransCon technology, which combines the benefits of prodrug and sustained release technologies, to develop a pipeline of best-in-class therapeutics that address significant unmet medical needs.
Thioether-lipid conjugates will be used to attach the ruthenium prodrugs to liposomes carriers that are well taken up by cancer cells.
It is based on a prodrug with four components: the actual cytotoxic agent, a ligand that recognizes one of the tumor-specific receptors, a "trigger" for the release, and a linker that holds everything together.
The day's big winner, Cascade Prodrug, was founded in September 2009 by biotech veterans Allan Cochrane and Augie Sick.
A prodrug is an inactive precursor of a drug that is converted into its active form in the body by normal metabolic processes.
The compound covered under this agreement has improved solubility and bioavailability after converted to a dihydrogen phosphonoxy methoxy derivative modified prodrug.
Fenethylline, also spelled Phenethylline and marketed under the brand name Captagon, is a synthetic prodrug used as a stimulant.
As a therapeutically inactive prodrug, Vyvanse contains D-amphetamine bonded covalently to I-lysine and is converted to pharmacologically active D-amphetamine after oral ingestion.
This patent covers Semafore's lead clinical candidate, SF1126, and other prodrug compositions of the widely studied PI3K inhibitor, LY294002, that Semafore is evaluating as a novel therapy for cancer and other diseases.
The enzyme only attaches to cancerous cells, so that when the prodrug is given it passes harmlessly through healthy tissue, targeting only a tumour.
Under terms of the agreement, Merck will contribute drug candidates to the collaboration and Metabasis will apply its liver targeting, HepDirect prodrug technology with the objective of identifying novel drugs for the treatment of the disease.