prometaphase


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prometaphase

[prō′med·ə‚fāz]
(cell and molecular biology)
A stage between prophase and metaphase in mitosis in which the nuclear membrane disappears and the spindle forms.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Inhibition of PLK1 causes mitotic arrest in prometaphase and subsequent cell death.
Interestingly, CENP-E is involved in the initial alignment of chromosomes at the spindle equator on the metaphase plate, and therefore, it is required for steady spindle microtubule capture at the kinetochores, which is a critical step in proper chromosome congression during prometaphase.
At prometaphase, 18S-25S rDNA sites also arrange peripherically and adjacent to each other (Fig.
PI, prophase I; PMI, prometaphase I; MI, metaphase I; MII, metaphase II; Egr3, early growth response protein 3; GV, germinal vesicle; IBMX, 3-isobutyl-1-methylxanthine.
Among these 8 pathway interactions, the DNA replication pathway (ID: 281) interacted with three pathways, i) APC/C-mediated degradation of cell cycle proteins (ID: 77), ii) regulation of mitotic cell cycle (ID: 850), and iii) mitotic prometaphase (ID: 602).
role of cyclin Bl/Cdc2 up-regulation in the induction of mitotic prometaphase arrest in human breast cancer cells treated with 2-methoxyestradiol.
As shown in Figure 3, based on the development of atomic out-of-plane displacement of the key point A, the wrinkling developing evolution can be divided into five stages, that is (I) prophase stage, (II) prometaphase stage, (III) metaphase stage, (IV) anaphase stage, and (V) telophase stage.
Microinjection of serum containing ACA into mouse oocytes could hinder chromosome congression and cause meiotic arrest in interphase or mitotic arrest in prometaphase [8].
The process of mitosis is divided into five stages: prophase, prometaphase, metaphase, anaphase, and telophase.
The SAC can prevent aneuploidy by delaying chromosome segregation at prometaphase or metaphase in response to unattached kinetochores and DNA damage during preimplantation development [9, 14-16].
Such upregulation of cyclin B1 usually activates cell cycle arrest in the mitotic prometaphase.