Inhibition of PLK1 causes mitotic arrest in prometaphase
and subsequent cell death.
Interestingly, CENP-E is involved in the initial alignment of chromosomes at the spindle equator on the metaphase plate, and therefore, it is required for steady spindle microtubule capture at the kinetochores, which is a critical step in proper chromosome congression during prometaphase
, 18S-25S rDNA sites also arrange peripherically and adjacent to each other (Fig.
PI, prophase I; PMI, prometaphase
I; MI, metaphase I; MII, metaphase II; Egr3, early growth response protein 3; GV, germinal vesicle; IBMX, 3-isobutyl-1-methylxanthine.
Among these 8 pathway interactions, the DNA replication pathway (ID: 281) interacted with three pathways, i) APC/C-mediated degradation of cell cycle proteins (ID: 77), ii) regulation of mitotic cell cycle (ID: 850), and iii) mitotic prometaphase
role of cyclin Bl/Cdc2 up-regulation in the induction of mitotic prometaphase
arrest in human breast cancer cells treated with 2-methoxyestradiol.
As shown in Figure 3, based on the development of atomic out-of-plane displacement of the key point A, the wrinkling developing evolution can be divided into five stages, that is (I) prophase stage, (II) prometaphase
stage, (III) metaphase stage, (IV) anaphase stage, and (V) telophase stage.
Microinjection of serum containing ACA into mouse oocytes could hinder chromosome congression and cause meiotic arrest in interphase or mitotic arrest in prometaphase
The process of mitosis is divided into five stages: prophase, prometaphase
, metaphase, anaphase, and telophase.
The SAC can prevent aneuploidy by delaying chromosome segregation at prometaphase
or metaphase in response to unattached kinetochores and DNA damage during preimplantation development [9, 14-16].
Such upregulation of cyclin B1 usually activates cell cycle arrest in the mitotic prometaphase