Pronormoblast | Article about pronormoblast by The Free Dictionary
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A nucleated erythrocyte precursor with scanty basophilic cytoplasm without hemoglobin. Also known as lymphoid hemoblast of Pappenheim; macroblast of Naegeli; megaloblast of Sabin; proerythroblast of Ferrata; prorubricyte; rubriblast; rubricyte.
References in periodicals archive
6 had NHL; (#) Giant pronormoblast
(Lantern cell) Seen; (##) atypical maculopapular rash over both lower limbs Table II.
14) The infected erythroid precursors suffer arrest of maturation beyond the normoblast stage leading to the formation of giant pronormoblasts
in the bone marrow and peripheral reticulocytopenia.
In patients with substantial loss of erythrocytes, proliferation and differentiation of more bone marrow pronormoblasts
may be initiated.
In pure red cell aplasia giant pronormoblasts
in the marrow are considered pathognomonic.
There are characteristic morphological features on the bone marrow biopsy such as red-cell maturation arrest and giant pronormoblasts
, but the bone marrow biopsy is not required for diagnosis.