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Observations over several decades have shown that Methimazole and its prodrug Carbimazole are better than Propylthiouracil in controlling more severe hyperthyroidism, having higher compliance rates, and causing less toxicity, especially when prescribed in lower doses4.
Mode of action: developmental thyroid hormone insufficiency--neurological abnormalities resulting from exposure to propylthiouracil.
Recommendation 13: Methimazole should be used in virtually every patient who chooses antithyroid drug therapy for GD [Graves" disease], except during the first trimester of pregnancy when propylthiouracil is preferred, in the treatment of thyroid storm, and in patients with minor reactions to methimazole who refuse radioactive iodine therapy or surgery.
Patients treated with propylthiouracil, a complete blood count should be done
The pill in question is propylthiouracil or methimazole to treat children with Grave's disease, the most common cause of an overactive thyroid, the Associated Press reported.
Effects of propylthiouracil, propranolol, and vitamin E on lipid peroxidation and antioxidant status in hyperthyroid patients.
Two medications are available to treat hyperthyroidism in pregnancy: propylthiouracil (PTU) and methimazole.
Hypothyroidism was induced by treatment with propylthiouracil (PTU).
Hyperthyroidism may be treated with the drugs methimazole (MMI) or propylthiouracil (PTU), radioactive iodine (the most popular choice) or surgery to remove part or all of the gland.
A second line of treatment is the use of the antithyroid medications propylthiouracil (PTU) and methimazole.
Astwood (67) for the management of Graves' disease in the forms of thiourea and thiouracil, these goitrogens evolved into more powerful ones, (68) and eventually the thionamides: methimazole, carbimazole, and propylthiouracil.
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