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Mechanism of inactivation of myeloperoxidase by propylthiouracil.
Propylthiouracil reduces xenograft tumor growth in an athymic nude mouse prostate cancer model.
Patients treated with daily doses of 300 milligrams of propylthiouracil had half the overall mortality rate of the group that received a placebo though nearly 40% of all subjects continued to drink moderately throughout the study.
Mode of action: developmental thyroid hormone insufficiency--neurological abnormalities resulting from exposure to propylthiouracil.
Severe liver injuries have been associated with use of the antithyroid drug propylthiouracil, and the FDA has added a boxed warning to the product's label conveying this risk, the agency announced.
Severe liver injuries have been associated with use of the antithyroid drug propylthiouracil, and the Food and Drug Administration has added a boxed warning to the product's label conveying this risk, the agency announced.
Antithyroid drugs, specifically thionamides (either propylthiouracil (PTU) or methimazole (MMZ)), are most often used as the primary treatment for persons with Graves' disease, in whom "remission," which is usually defined as remaining biochemically euthyroid for one year after cessation of drug treatment, is possible (9).
Typical initial dose for propylthiouracil is 100 mg four times daily and for methimazole, 10 mg four times daily.
Her physician has prescribed propylthiouracil daily, but the patient has been noncompliant with medication in the past.
Some hyperthyroid patients are given antithyroid drugs such as propylthiouracil (PTU) or methimazole (Tapazole).
In younger patients with mild disease, such drugs as propylthiouracil or methimazole may slow down thyroid hormone production.
Since there was active ophthalmopathy and the patient did not want to receive propylthiouracil for a long time, we have decided that total thyroidectomy was the best option for definitive therapy.
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