protease inhibitor


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Related to protease inhibitor: fusion inhibitor, Serine protease inhibitor

protease inhibitor

(prō`tē-ās'), any of a class of drugs that interfere with replication of the AIDSAIDS
or acquired immunodeficiency syndrome,
fatal disease caused by a rapidly mutating retrovirus that attacks the immune system and leaves the victim vulnerable to infections, malignancies, and neurological disorders. It was first recognized as a disease in 1981.
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 virus (HIVHIV,
human immunodeficiency virus, either of two closely related retroviruses that invade T-helper lymphocytes and are responsible for AIDS. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States.
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), by blocking an enzyme (protease) necessary in the late stages of its reproduction. Clinical trials of the protease inhibitor indinavir have shown it to be especially beneficial in combination with the anti-HIV drugs AZTAZT
or zidovudine
, drug used to treat patients infected with the human immunodeficiency virus (HIV), which causes AIDS; also called azidothymidine. Originally developed in 1964 as an anticancer drug, AZT was never approved for that purpose.
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 and 3TC, which act by blocking a different enzyme, reverse transcriptase. Saquinavir, the first member of the class to be marketed, was approved for use in 1995 by the Food and Drug Administration.
References in periodicals archive ?
Therefore, LC-pi I, a potent protease inhibitor may have the potential to serve a lead compound for the development of novel antimicrobial drug.
Among people in whom Prezista failed, lower proportions lost sensitivity to protease inhibitors (PIs) or nucleoside reverse transcriptase inhibitors (NRTIs) they were taking when compared with people in whom Kaletra failed.
The use of viral load testing in studies investigating the protease inhibitors was another cause for excitement.
The study included all women treated with protease inhibitors at five centers from December 1997 through December 2001.
Already, we have been able to advance several potent small molecule hepatitis C virus protease inhibitors into pharmacokinetic evaluation, and we could select a drug development candidate as early as 2001.
You may take your protease inhibitor two or three times every day, depending on which one you take.
For HIV-infected patients diagnosed with drug-susceptible TB and for whom protease inhibitor therapy is being considered but has not been initiated, the suggested management strategy is to complete TB treatment with a regimen containing rifampin before starting therapy with a protease inhibitor.
WASHINGTON - Protease inhibitors, a new class of antiviral drugs being developed by major pharmaceutical manufacturers, are being hailed as a major step forward in the battle to control AIDS.
Gives Impact analysis of approval of Victrelis (boceprevir) - First-in-Class Oral Hepatitis C Virus (HCV) Protease Inhibitor Approval in US
Delayed switching from a failing protease inhibitor combination did not increase the risk of death or CD4-count failure during the study period.
They traced the drop-off in sulfur-based amino acids to a lower content of a particular protein called Bowman-Birk protease inhibitor.