protein kinase


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Related to protein kinase: Protein kinase C, Protein kinase B

protein kinase

[¦prō‚tēn ′kī‚nās]
(biochemistry)
An enzyme that exerts regulatory effects on growth and malignant transformation by phosphorylating proteins.
References in periodicals archive ?
Recombinant protein kinases, optimized for crystallization, will be produced and exclusively marketed by ProQinase, while CRELUX will continue to provide customers with crystallization and X-ray crystallography services.
Although the cellular target of Pb is still elusive, exposure to Pb activates protein kinase C (PKC) in several types of cells, such as astrocytes and neuronal cells in the brain (Costa 1998; Markovac and Goldstein 1988).
We feel that the PLK1-B23 phosphorylation story nicely demonstrates the power of the Kinetworks(TM) approach to rapidly and cost-effectively discover protein kinase drug targets and the means to identify their inhibitors" said Dr.
This approach was practically tested for protein kinase A reaction with its specific peptide substrate LRRASLG (Kemptide) [10].
HIV-1 gp120 and chemokine activation of pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling.
These studies demonstrate, by using immunological and functional criteria, that Xenopus oocytes have a Ku-like protein that is associated with the activity of DNA-dependent protein kinase (DNA-PK).
More specifically, this new intellectual property covers the use of protein kinase N 3 (PKN3) for screening of therapeutic agents, thus preventing others from using PKN3 for screening purposes.
In that situation, the IKKE protein kinase acts as a brake on the metabolism.
Overexpression of cyclin-dependent kinase inhibitor 1 (WAF1) from the kinase inhibitor protein group and PAK-[gamma] (p21- activated kinase [gamma]), combined with overexpression of CDKN2D (p19-INK4D) and cell division protein kinase 3 (CDK3), denote a major derangement in the regulation of cell-cycle progression.
Many of these proteins are linked to protein kinase C, a signaling molecule whose role in development and function, as well as in learning and memory, has been intensively studied.
The rats showed long-lasting increases in an enzyme called protein kinase A, which in turn caused greater release of the chemical messenger GABA.

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