Lead activates protein kinase C
in immature rat brain microvessels.
Steve's extensive experience in operational and financial management, business development and commercialization strategy will be invaluable to KAI as the company rapidly advances its clinical and preclinical therapeutic pipeline of protein kinase C
modulators for the acute treatment of ischemia and reperfusion injury and for diseases involving chronic regulation of angiogenesis.
In our study, 1 and 5 mM nickel in the presence of fibrinogen induced platelet aggregation (independently of protein kinase C
activation) and secretion.
Chair of the Department of Molecular Pharmacology at Stanford University, to develop therapeutics that selectively modulate protein kinase C
(PKC), a well validated pharmaceutical target.
Intracellular lead may also activate protein kinase C
and various calmodulin-dependent enzymes, such as calmodulin-dependent protein kinase, phosphodiesterase, and calcineurin, at picomolar concentrations.
Ongoing research emphasizes 1) protein kinase C
and MAP kinase signaling pathways induced by fatty acids in tumor cells in vitro, 2) mechanisms of tumor cell adhesion, migration, and invasion in vitro, 3) alterations in cytoskeletal structures in metastatic tumor cells, and 4) the role of protein glycosylation in tumor cell behavior.