protein kinase

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Related to Protein kinases: Phosphatases

protein kinase

[¦prō‚tēn ′kī‚nās]
(biochemistry)
An enzyme that exerts regulatory effects on growth and malignant transformation by phosphorylating proteins.
References in periodicals archive ?
Abbreviations CaMKII: Calcium/calmodulin-dependent protein kinase II AUC: Area under the curve PSD: Postsynaptic density.
Feng et al., "Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver," Journal of Lipid Research, vol.
Atypical PKCs (including protein kinase [zeta] and [iota]/[lambda] isoforms), which belong to the PKC family, require neither calcium nor diacylglycerol for activation.
In consequence, the aforementioned information adopted in the existing methods may not fully determine the corresponding protein kinase. It is well known that one protein kinase can catalyze multiple phosphorylation sites and one phosphorylation site can also be phosphorylated by multiple protein kinases [22-24].
AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.
However, under oxidizing conditions, the increased level of intracellular ROS promotes the dissociation of Nrf2 and Keap1, either by the oxidization of key reactive cysteine residues (Cys273, Cys288, and Cys151) that govern Keap1 activity or via the activation of kinases, such as protein kinase C (PKC), MAPK, phosphatidylinositide 3-kinases (PI3Ks), and protein kinase-like endoplasmic reticulum kinase (PERK) that phosphorylate Nrf2 [79-81].
Gutkind, "A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5," Molecular and CellularBiology, vol.
The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation.
MAP kinase-activated protein kinase 2 (M2) and M3 were the first p38 substrates identified [63, 64].
Kinase activity activated with SGL-II was inhibited by the addition of protein kinase inhibitor peptide, a specific peptide inhibitor for cAMP-kinase.
In some cases, activation of AMPK requires phosphorylation of T-172 by an upstream protein kinase such as LKB1 (Hawley et al., 1996).

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