proteoglycan


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proteoglycan

[‚prōd·ē·ō′glī·kən]
(biochemistry)
A high-molecular-weight polyanionic substance covalently linked by numerous heteropolysaccharide side chains to a polypeptide chain backbone.
References in periodicals archive ?
Changes of proteoglycan and collagen II of the adjacent intervertebral disc in the cervical instability models.
They revealed that the carbohydrate that the malaria parasite attaches itself to--an oncofetal chondroitin sulfate (CSA)--which is expressed in the placenta is the same as the one displayed on proteoglycans in cancerous cells (the placental and malignant compartments display a common CS signature that binds malarial protein,VAR2CSA,) (Figure 7).
Proteoglycans and their attached glycosaminoglycans are closely associated with collagen fibers and these interactions play a dominant role in the maintenance of tissue structure and cell adhesion [15,16].
Olczyk, "Circulating keratan sulfate as a marker of metabolic changes of cartilage proteoglycan in juvenile idiopathic arthritis; influence of growth factors as well as proteolytic and prooxidative agents on aggrecan alterations," Clinical Chemistry and Laboratory Medicine, vol.
The present study was undertaken to evaluate if proteoglycan (PG) injected by intraperitoneal (i.
OUMS-27 cell line secretes cartilage-specific proteoglycans, and type-2 and -9 collagens.
Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia) Nat Genet.
Proteoglycans produce a sticky quagmire, trapping and restricting the cut nerve fiber tips (called growth cones) from making their journey back to their proper synaptic connections.
Nucleus pulposus notochord cells secrete connective tissue growth factor and up-regulate proteoglycan expression by intervertebral disc chondrocytes.
1996) Distribution of the large aggregating proteoglycan versican in adult human tissues.
The Safranin O staining revealed changes in the proteoglycan profile in the injury groups.
Papain destroys the core protein collagen chain and proteoglycan aggregates leading to loss of cartilage integrity (Murat et al.