The markets for proteomic
technologies are difficult to estimate as they are not distinct but overlap with those of genomics, gene expression, high throughput screening, drug discovery and molecular diagnostics.
Mass spectrometry has developed as a key platform for proteomic
analyses, with two contrasting approaches which are bottom-up and top-down proteomics
Translation of proteomic
biomarkers into FDA approved cancer diagnostics: issues and challenges.
CPTAC continues to define the most rigorous standards for proteomic
The major objective of proteome research is to identify and characterize the comprehensive responses of a cell or biological system to different stimuli.[sup] The emerging proteomic
studies largely depend on the advances in protein separation, identification technology, and bioinformatics.
Because proteogenomics is most dependent on the availability of high-quality proteomic
data, the technologies that enable sensitive, large-scale proteome profiling are of the highest importance.
Studies in Acute Hypoxic Respiratory Failure." PhD diss., UNIVERSITY OF MINNESOTA, 2015.
With next generation sequencing analysis also available from the same sample, this innovative approach allows for multiple targeted proteomic
and genomic results from a biopsy specimen.
By permitting the simultaneous assessment of multiple analytes, NGS and MS proteomics
are challenging the traditional concept of using focused, low-throughput companion diagnostics, such as immunohistochemistry and fluorescence in situ hybridization, in favor of a more expansive assessment of the molecular and proteomic
makeup of cancer samples.
Researchers in various medical and biological specialties focus mostly on preparing samples for proteomic
and metabolomic studies, rather than on using the imaging equipment.
analysis detects the gene expression during different life activities (e.g.
Systems biology is essentially a proteomic
and epigenetic exercise because the relatively condensed information of genomes unfolds on the level of proteins.