proto-oncogene


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Related to proto-oncogene: tumor suppressor gene

proto-oncogene

[¦prō·dō ′äŋ·kōjēn]
(genetics)
The normal-functioning precursor of an oncogene; mutation of this gene to produce an oncogene causes excessive activity of the gene product, leading to cancer.
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References in periodicals archive ?
To address the molecular pathogenesis of PCNSL, many studies have been focused on mutations of proto-oncogenes and tumor suppressor genes.
The report reviews Myc Proto-Oncogene Protein (Proto-Oncogene c-Myc or Class E Basic Helix-Loop-Helix Protein 39) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Hiai, "Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains," Oncogene, vol.
The role of c-Fos proto-oncogene was examined by several types of experimental models in the rat brain, each securing global transient ischemia, followed by unilateral or bilateral cerebral ischemia.
Qualitative: Conversion from proto-oncogene to transforming gene includes changes in the nucleotide sequence and acquisition of the new properties.
Imatinib binds preferentially to ATP binding sites of c-KIT proto-oncogene product, platelet-derived growth factor receptor (PDGF-R), and Abelson Kinase (c-ABL), impeding the ensuing signal transduction.
Expression of c-met proto-oncogene in primary colorectal cancer and liver metastases.
MET proto-oncogene has been shown to be over-expressed in 40% of lung cancers (11) and MET gene amplification has been shown to lead to EGFR inhibitor resistance.
The c-erbB2 proto-oncogene is a member of the Erb B family of transmembrane tyrosine kinase receptors.
For instance, a wrong base change in a proto-oncogene can lead to cancer, or possessing less copies of a gene that produces a viral co-receptor might make someone more susceptible to infection.
10) descreveram alteracoes geneticas no proto-oncogene germinativo de transicao epitelio mesenquimal em 70% dos caes da raca rottweilers e acredita-se que este esteja ligado ao desenvolvimento neoplasico, ja que caes desta raca apresentam alta frequencia de desenvolvimento de tumores.