Statistical analysis that weighed the impact of numerous fracture risk factors identified 7 that were independently associated with higher fracture risk regardless of whatever other risk factors a person had--white race, cerehrovascular disease or stroke, alcohol-related diagnoses, current proton pump inhibitor
use, current protease inhibitor use, higher VACS Index score, and lower body mass index when entering the study group (Figure 1).
The company estimates that 15 million people in the United States currently are taking proton pump inhibitors
for GERD, and that between 10 percent and 15 percent of those may be candidates for a device such as Enteryx.
Association of long-term proton pump inhibitor
therapy with bone fractures and effects on absorption of calcium, vitamin B12, iron, and magnesium.
Accumulating evidence has confirmed the excellent efficacy and safety of proton pump inhibitor
(PPI) therapy in patients with all grades of GERD, making these agents the mainstay of treatment.
NEW ORLEANS--More than half the physicians using proton pump inhibitors
to treat acid reflux-induced asthma aren't using the optimal dosing regimen for nighttime incidents.
The first published head-to-head study of five currently marketed brand name proton pump inhibitors
(PPIs) demonstrates that AstraZeneca's NEXIUM(R) (esomeprazole magnesium) provides excellent suppression of gastric (stomach) acid production compared to four other marketed proton pump inhibitors
(PPIs), according to new research published today in the December issue of the American Journal of Gastroenterology.
When omeprazole (Prilosec) came onto the market in the mid-1980s as the first proton pump inhibitor
approved for use in the United States, many experts were concerned that long-term, chronic use might raise a patient's risk of gastric carcinoids.
Findings from an uncontrolled study showed that treatment with a proton pump inhibitor
and trazodone improved severe, spasmodic chest pains in 80% of a group of patients with "nutcracker esophagus," a motility disorder characterized by high-amplitude peristaltic contractions arising from the distal esophagus.
POZEN has development and commercialization alliances with GlaxoSmithKline for the proposed product candidate Trexima[TM] combining sumatriptan, formulated with RT Technology[TM], and naproxen sodium in a single tablet for the acute treatment of migraine, which is currently under review by the United States Food and Drug Administration, and with AstraZeneca for proprietary fixed dose combinations of naproxen with the proton pump inhibitor
esomeprazole magnesium in a single tablet for conditions such as osteoarthritis and rheumatoid arthritis in patients who are at risk for developing NSAID-associated gastric ulcers.
It also suggests that a clinical trial of a combination of ibuprofen and a proton pump inhibitor
might be effective for those already suffering from Alzheimer disease," he added.
Patients whose heartburn is unrelieved by proton pump inhibitors
probably do not have GERD.
Reduction in Uncomplicated Upper Gastrointestinal Events was Consistent with or without Use of Proton Pump Inhibitors
and Maintained in Patients Taking Low-Dose Aspirin Regularly