The opening of the proximal convoluted tubule
is 10.9% (P[less than or equal to]0.05) narrowed.
A peculiar finding in our study was that epithelial cells of the renal proximal convoluted tubules
of NHP and guinea pigs contained VP40 antigen, yet they did not appear to be infected with the virus.
The tubule structures completely or partly inside the counting frame but only touching the top and right lines are considered (here four proximal convoluted tubules
) (PAS, 400x).
A; the mean diameter of distal convoluted tubule, B; the mean diameter of proximal convoluted tubule
C; the mean diameter of glomerulus.
We developed a new algorithm to calculate the fractal dimension of convoluted objects, like the outline images of a serially sectioned proximal convoluted tubule
. The resulting algorithm is intermediate between box-counting and perimeter-stepping algorithms (Cross, 1994).
In this study, sodium cyclamate produced in the kidneys of rat fetuses statistically significant morphometric changes in the glomerulus, distal and proximal convoluted tubules
, and collecting duct, suggesting nephrotoxicity.
The current findings suggested that proximal convoluted tubules
were the frequently affected renal tubular cells, that attributed to cellular metabolic pathways are greatly vulnerable to nephrotoxic agents as DS (Elsayed et al., 2014).
Distal convoluted tubules exhibiting flat cuboidal cells with moderate acidophilia and large nuclei were observed, whereas other cuboidal cells exhibited proximal convoluted tubules
, centrally located large nuclei and microvilli, thus characterizing a brush-shaped surface (Figure 5).
Histopathological examination of group B mice which received gentamicin only, exhibited marked degeneration in proximal convoluted tubules
. Fragmented tubular basement membrane and proteinacoeus cast in the lumen were observed.
In group B animals, the diameter of proximal convoluted tubules
increased, the number of proximal convoluted tubules
and their nuclei decreased, whereas diameter of the nuclei decreased after an initial increase during the first and second weeks.
The predominant lesion in patients with acute renal failure is acute necrosis and is located mostly in the proximal convoluted tubules
. The severity ofnecrosis is dependent on dose, concentration, and duration.
Jacobson, "Angiotensin II directly stimulates sodium transport in rabbit proximal convoluted tubules
," The Journal ofClinical Investigation, vol.