proximal convoluted tubule

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Related to Proximal tubule: loop of Henle, Distal tubule

proximal convoluted tubule

[′präk·sə·məl ‚kän·və′lüd·əd ′tüb‚yül]
(anatomy)
The convoluted portion of the vertebrate nephron lying between Bowman's capsule and the loop of Henle; functions in the resorption of sugar, sodium and chloride ions, and water.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Segmental loss of integrity of the proximal tubule with absent microvillous border and cell fragments in the tubular lumen (uranyl acetate and lead citrate, original magnification X7500).
McLay, "Cytokine-stimulated nitric oxide production in the human renal proximal tubule and its modulation by natriuretic peptides: a novel immunomodulatory mechanism?" Experimental Nephrology, vol.
We have previously demonstrated that high glucose and the PPAR[gamma] ligand, pioglitazone, induce PPAR[gamma] expression [16] and that PPAR[gamma] agonists upregulate the main sodium and water channels in the proximal tubule, NHE3 and AQP1 protein expression, through an Sgk1 mediated pathway, which is considered to be a significant modifier of cellular volume in conditions of osmotic stress [22].
Ouabain-insensitive [Na.sup.+]-ATPase of proximal tubules is an effector for urodilatin and atrial natriuretic peptide.
The renal cortical tissue was used for proximal tubule isolation or mitochondria isolation.
arenarum, strong E-cadherin immunoreactivity is detected on the cell surface of the developing Mesonephros proximal tubules (Figures 3a) and a weak immunoreactivity is detected in the collecting ducts and in few undifferentiated mesonephrogenic mesenchymal cells (Figures 3b-c).
However, this transition has long been hindered by the lack of a feasible and ethical means of delivering and sampling from an isolated human proximal tubule in vivo.
Once synthesized on the skin by UV rays from 7-dehydrocholesterol, cholecalciferol (vitamin D3) is converted to 25-hydroxy-cholecalciferol in the liver, and then to 1,25-dihydroxy-cholecalciferol in the mitochondria of renal proximal tubule cells.
Encoded in the GNAS gene locus, Gsa production in PPR-producing renal proximal tubule cells is dependent on the maternal allele, owing to silencing of the paternal allele via mechanisms not yet fully understood.
In the kidney, siRNA stabilized with 2'O-methylation is filtered and reabsorbed in the renal proximal tubule (PT) following IV administration, reducing relative mRNA expression temporarily in the PT [9].
They compared ischemia reperfusion injury between the selective renal proximal tubule survivin knockout mice and a control group.
Supportive findings include the expression of proximal convoluted tubule markers (CD10 and alpha-methylacyl-CoA racemase; AMACR), distal nephron proteins (parvalbumin, high-molecular-weight CK, and CD19) [1, 6], and the detection of intercalated cells and cells similar to those in the proximal tubule using electron microscopy [1, 7, 8].