Prurigo

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Prurigo

 

a skin disease characterized by severe itching and the appearance of nodular eruptions, bloody crusts, and lesions from scratching, predominantly on the extensor surfaces of the extremities, abdomen, back, lumbar region, and buttocks.

Sensitization of the body to food products and medications, as well as hereditary factors, play an important role in the development mechanism of prurigo. The skin of prurigo patients is dry, and the lymph nodes are enlarged; neurotic disorders and insomnia are observed. A distinction is made between infantile, adult, and nodular prurigo. Infantile prurigo is usually observed in infants that have a tendency toward an exudative diathesis. The disease is usually localized on the face and the scalp. Nodular prurigo is characterized by a small number of grayish-brown nodules ranging from the size of a pea to a hazelnut and by chronic relapses. Treatment consists in desensitizing, antihis-taminic, and tranquilizing agents; diet; external antipruritic preparations of magma or corticosteroid ointments; and sanatorium-health resort treatment.

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Treatment of prurigo nodularis with thalidomide: a case report and review of the literature.
In ceea ce priveste simptomatologia cutanata, aceasta poate varia de la asimptomatic pana la prezenta excoriatiilor post-grataj sau lichenificare, prurigo nodularis sau chiar ulceratii postgrataj.
Prurigo nodularis is a chronic skin condition characterized by numerous intensely pruritic, symmetrically distributed, erosive nodular lesions.
After the primary lesion emerged the patient developed multiple 5-6mm tumors on the extensor side of arms, lower limbs, and postauricular, which clinically presented as prurigo nodularis. The patient did not have a personal or family history of skin disorders.
This conclusion is further supported by reports that aprepitant is more effective at relieving pruritus in patients with prurigo nodularis, as prior studies have found that patients with prurigo nodularis have an increased number of nerve fibers positive for SP [5, 31].
The lesions which are maximally diagnosed in our study are leprosy, erythema nodosum leprosum, cutaneous tuberculosis, trichoepithelioma, Prurigo Nodularis, actinomycosis, granuloma annulare, epidermoid cyst, syringoma, Jessener lymphocytic infiltrate, basal cell carcinoma (BCC), and metastatic carcinoma.
Diagnosis of other skin diseases amongst subjects in Group 3 included: 13 contact/allergic dermatitis (34%); 7 tinea infection (18%); 4 seborrheic dermatitis (11%); 3 psoriasis (8%); 2 prurigo nodularis (5%) cases; 2 acune (5%) cases; and 7 otherconditions/diseases (18%) were coagulopathy suspected (pytiriasis rosea, striae distensae, carbunculosis, neurodermatitis, verruca plana, and lichen planus).
Prurigo nodularis as initial presentation of metastatic transitional cell carcinoma of the bladder.
Disease Frequency (n) Percentage(%) Yellow discoloration 93 43.3 Hyperpigmentation 77 35.8 Pallor 65 30.2 Ecchymosis 23 10.7 Solar elastosis 17 7.9 Pruritus Generalised 62 28.8 Localised 42 19.5 Xerosis 127 59.1 Prurigo nodularis 4 1.9 Lichen simplex 2 0.9 chronicus Excoriation 5 2.3 Absence of lunulae 30 14.0 Splinter haemorrhage 41 19.1 Leukonychia 2 0.9 Longitudinal ridging 55 25.6 Half-and-half nail 26 12.1 Koilonychia 22 10.2 Onycholysis 1 0.5 Contact dermatitis 1 0.5 Folliculitis 11 5.1 Furunculosis 2 0.9 Delayed wound healing 3 1.4 Table 2: The relationship between skin disease and occupation.
The firm aims to use the funding for starting pivotal trials for two severe itch conditions, uremic pruritus and prurigo nodularis. It aims to start both pivotal trials in the third quarter of 2014, and expects to have top-line results in the second half of 2015.
Release date- 21082019 - Johns Hopkins researchers report that prurigo nodularis (PN), a skin disease characterized by severely itchy, firm bumps on the skin, may be associated with other inflammatory skin disorders as well as systemic and mental health disorders.