is a late-stage biopharmaceutical company focused on the development of serlopitant, a once-daily oral NK1 receptor antagonist, for the treatment of pruritus
. The company's clinical development program for serlopitant covers three indications and includes two ongoing Phase 3 clinical trials for the treatment of pruritus
associated with prurigo nodularis, a Phase 3-ready clinical program for the treatment of pruritus
associated with psoriasis, and a Phase 2 clinical trial for the treatment of chronic pruritus
of unknown origin.
New Study On "Global Pruritus
Drugs Market Share, Supply, Analysis and Forecast to 2025" Added to Wise Guy Reports Database
The company also announced it is developing BLU-5937 for the treatment of chronic pruritus
Dr Adil Sheraz, consultant dermatologist and British Skin Foundation spokesperson, said, "Aquagenic pruritus
is an uncommon and distressing condition that results in severe itching almost immediately after contact with water.
and pain resolved completely, and after 6 months of treatment with trametinib, repeat MRI "revealed decreased thickening of the dermis and near resolutions of muscular invasion." According to the patient's family, her quality of life improved dramatically.
Most importantly, generalized pruritus
can represent the manifestation of a systemic disease.
Notalgia paresthetica je ucestalo, iako slabo prepoznato stanje koje obiljezava lokalizirani kronicni pruritus
gornjeg dijela leda, a najcesce se javlja u zena srednje zivotne dobi.
Specific substances such as Menthol and Camphor are higher in percentage that is 2.6% and 4.73% respectively,1 they attenuate the excitability of nerve membranes and of the specific itch mediating C-fibers and A-fibers.2 Both substances act by attaching to the transient receptor potential (TRP) receptor, but the main mechanism of action by which topical menthol reduces pruritus
is by attaching onto the cold receptor TRPM8 which then goes and reaches the A-delta fibers and hence giving a cooling sensation.2 While camphor attaches onto the warm receptor TRPV3.3 Furthermore, menthol also helps in providing general anaesthesia by being a positive modulator of GABA type a receptor.
Additionally, the activation of peripheral KORs also been shown to produce potent anti-itching activity in uremic pruritus
. Because KORs are also expressed in the brain where they trigger adverse effects, it is necessary to prevent brain penetration when targeting peripheral KORs, concluded the company.
TUESDAY, April 24, 2018 (HealthDay News) -- Serlopitant has potential as a therapy for the treatment of chronic pruritus
, according to a study published in the May issue of the Journal of the American Academy of Dermatology.
Describe the epidemiology and clinical features of uremic pruritus