Hyperplastic epithelium and pseudostratification
can be observed.
Protruding polyp composed of cells resembling gastric foveolar-type epithelium with nuclear pseudostratification
. All tumor cells are positive for MUC5AC (inset) (hematoxylin-eosin, original magnification X20; original magnification X10 [inset]).
The cells showed mild to moderate nuclear enlargement, hyperchromasia and sometimes pseudostratification
, but high-grade nuclear features were not seen (Figs.
Cytological atypia was less than Figures 4(a) and 4(b); however they have mild nuclear atypia and pseudostratification
. (d) H-E stain.
Focally, the columnar goblet cell nuclei were slightly enlarged and hyperchromatic with pseudostratification
MICROSCOPY FINDING: The cyst is partially lined by low columnar to cuboidal cells, which exhibits pseudostratification
; part of the cyst is lined by squamous epithelium probably due to squamous metaplasia of the pseudostratified columnar epithelium.
Other important features are lack of polarity pseudostratification
, striking pleomorphism, brisk mitosis, and single cell apoptosis, feature which are absent in endometrioid adenocarcinomas .
Eosinophilic, granular, but less voluminous cytoplasm and focal nuclear pseudostratification
characterized this area.
Another features mentioned include increase nuclear size, nuclear pseudostratification
, variable amounts of mitoses and regular or irregular over-struck tubular structures and ramifications (1).
The prostatic acini affected by PIN showed a remarkable enlargement of the epithelial layer with pseudostratification
and crowding of the nuclei in comparison with normal acini from controls.
and rare mitosis were occasionally seen, but by definition, these tumors are devoid of complex architectural abnormalities or nuclear atypia.
and there are scattered mitotic figures.