130) Type 1 papillary RCCs contain papillae covered by small cells with scant cytoplasm arranged in a single layer; type 2 tumors are characterized by tumor cells of higher nuclear grade, pseudostratification
of nuclei, and abundant eosinophilic cytoplasm (Figure 3, A).
Focally, the columnar goblet cell nuclei were slightly enlarged and hyperchromatic with pseudostratification
Eosinophilic, granular, but less voluminous cytoplasm and focal nuclear pseudostratification
characterized this area.
Another features mentioned include increase nuclear size, nuclear pseudostratification
, variable amounts of mitoses and regular or irregular over-struck tubular structures and ramifications (1).
The prostatic acini affected by PIN showed a remarkable enlargement of the epithelial layer with pseudostratification
and crowding of the nuclei in comparison with normal acini from controls.
of epithelial cells along with increased epithelial apoptosis and ring mitoses can mimic dysplasia.
and there are scattered mitotic figures.
The villi were lined by mucin producing columnar epithelial cells with nuclear crowding, pseudostratification
, and hyperchromasia, consistent with intestinal type low grade dysplasia (Fig.
Type 2 papillary RCC shows nuclear enlargement, eosinophilic cytoplasm, and nuclear pseudostratification
and can lack the characteristic foamy macrophages within the fibrovascular cores (Figure 5, A through D).
Focal intestinal type epithelium, tufting and pseudostratification
with mild nuclear atypia were present, qualifying the tumour as a mucinous neoplasm of low malignant potential or "borderline" type (Fig.
9) Further, BilIN is histologically classified as classic type--consisting of columnar/cuboidal cells with eosinophilic cytoplasm and round nuclei--and intestinal type--characterized by columnar cells with elongated and hyperchromatic nuclei, nuclear pseudostratification
, and occasional goblet-type cytoplasmic mucin resembling intestinal adenoma.
for practical purposes, large lesions with abnormal proliferation, dilated distorted crypts, dilatation of the base of the crypts, and/or focal nuclear atypia with pseudostratification