psoriasis

(redirected from psoriatic)
Also found in: Dictionary, Thesaurus, Medical, Wikipedia.
Related to psoriatic: psoriatic arthritis, psoriatic nails

psoriasis

(sôrī`əsĭs), occasionally acute but usually chronic and recurrent inflammation of the skin. The exact cause is unknown, but the disease appears to be an inherited, possibly autoimmune disorder that causes the overproduction of skin cells. Psoriasis may occur at any age but is uncommon in children. The characteristic lesion is a scaly "mother-of-pearl" patch, appearing anywhere on the body. Involvement may range from a single plaque to numerous patches that cover most of the skin. A variety of treatments are used for patients with mild to moderate cases. Treatments directed at the symptoms include the application of ointments and exposure to sunlight and ultraviolet (UVB) light. Retinoids help stabilize follicular epithelial cells. Vitamin D analogs and metabolites, although effective in treatment, have side effects. Photochemotherapy (psoralen combined with UVA radiation) is also effective, but increases the risk of skin cancer. Alfacept and other drugs that interfere with T-cell (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
..... Click the link for more information.
) activation, and etanercept, infliximab, and other drugs that block tumor-necrosis factor are effective in many patients with moderate to severe psoriasis.
The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved. www.cc.columbia.edu/cu/cup/
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Psoriasis

 

a chronic recurrent noncontagious skin disease of man. Neuropsychic traumas and metabolic and endocrine disorders play a part in the development of psoriasis. The disease may also be viral or genetic in nature.

Eruptions may appear anywhere on the skin but generally occur on the elbows, knees, sacral region, and scalp. The disease becomes acute with the appearance of small pink-red papules covered with silvery scales that readily slough off. When the papules are scraped, the scales fall off in small particles, revealing a smooth shiny surface underneath. Further scraping produces small drops of blood. The papules rapidly enlarge, often coalescing to form plaques. This process may be circumscribed, disseminated, or generalized (erythroderma psoriaticum). When the papules and plaques reach a certain size, they stop growing and then harden, shrink, and disappear, leaving depigmented or hyperpigmented spots.

There are thus three stages of psoriasis: progressive (appearance and growth of papules), stationary (stable), and regressive (hardening and disappearance of papules). Sometimes the nail plates are affected, and their surface becomes thimble-like. In some patients, the eruptions are accompanied by swelling and tenderness of the joints (psoriasis anthropathica).

Treatment is effected by administering vitamins A, B1, B6, and B12, tranquilizers, and hormones, by means of ultraviolet radiation and application of paraffin and desquamative and resorbing ointments, and by health-resort therapy.

REFERENCE

Mashkilleison, L. N. Chastnaia dermatologiia. Moscow, 1965. Pages 161–216.

I. IA. SHAKHTMEISTER

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.

psoriasis

[sə′rī·ə·səs]
(medicine)
A usually chronic, often acute inflammatory skin disease of unknown cause; characterized by dull red, well-defined lesions covered by silvery scales which when removed disclose tiny capillary bleeding points.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.

psoriasis

a skin disease characterized by the formation of reddish spots and patches covered with silvery scales: tends to run in families
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
Data from the two DISCOVER studies will serve as the basis of submissions to the US Food and Drug Administration and European Medicines Agency seeking approval of guselkumab as a treatment for psoriatic arthritis, which are anticipated for later this year.
Very few studies have been conducted in our region to look at serum uric acid levels in psoriatic patients4.
This MHLW approval is based on efficacy and safety data from the company's Phase 2 and Phase 3 clinical trials, sustaIMM, ultIMMa-1 and IMMspire, evaluating SKYRIZI in Japanese patients with plaque psoriasis, generalised pustular psoriasis and erythrodermic psoriasis, as well as a global Phase 2 study in patients with active psoriatic arthritis.
The psoriatic KCs were seeded in culture flask filled with defined KC serum-free medium supplemented with growth supplement and bovine pituitary extract (Gibco).
Psoriatic arthritis responds less well to current treatments, and no diagnostic test for psoriatic arthritis yet exists.
(18) did not find any difference in the percentage of Treg cells between psoriatic and healthy patients.
Here, the authors report the case of a patient with PsA in the hands, psoriatic nail changes without accompanying psoriasis of the skin, and concomitant active AD.
Studies showed that psoriatic patients have an increased risk of psychiatric comorbidities and suicidal ideation compared to patients suffering from other dermatological diseases such as melanoma and allergic disorders [7, 8].
Psoriatic arthritis (PsA) is a type of inflammatory arthritis characterized by cutaneous psoriasis, peripheral joint damage, axial joint damage, and enthesitis and is usually diagnosed after the appearance of psoriatic skin disease.
Psoriatic arthritis (PsA) has been defined as inflammatory arthritis, usually seronegative, associated with psoriasis [1].
LL37 forms a complex with these self-nucleic acids to activate TLRs 7-9 in dendritic cells (DCs), which results in the production of various proinflammatory cytokines that further activate other cell types, such as T cells and keratinocytes, and generate chronic psoriatic inflammation [28-33].