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Related to psoriatic: psoriatic arthritis, psoriatic nails


(sôrī`əsĭs), occasionally acute but usually chronic and recurrent inflammation of the skin. The exact cause is unknown, but the disease appears to be an inherited, possibly autoimmune disorder that causes the overproduction of skin cells. Psoriasis may occur at any age but is uncommon in children. The characteristic lesion is a scaly "mother-of-pearl" patch, appearing anywhere on the body. Involvement may range from a single plaque to numerous patches that cover most of the skin. A variety of treatments are used for patients with mild to moderate cases. Treatments directed at the symptoms include the application of ointments and exposure to sunlight and ultraviolet (UVB) light. Retinoids help stabilize follicular epithelial cells. Vitamin D analogs and metabolites, although effective in treatment, have side effects. Photochemotherapy (psoralen combined with UVA radiation) is also effective, but increases the risk of skin cancer. Alfacept and other drugs that interfere with T-cell (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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) activation, and etanercept, infliximab, and other drugs that block tumor-necrosis factor are effective in many patients with moderate to severe psoriasis.



a chronic recurrent noncontagious skin disease of man. Neuropsychic traumas and metabolic and endocrine disorders play a part in the development of psoriasis. The disease may also be viral or genetic in nature.

Eruptions may appear anywhere on the skin but generally occur on the elbows, knees, sacral region, and scalp. The disease becomes acute with the appearance of small pink-red papules covered with silvery scales that readily slough off. When the papules are scraped, the scales fall off in small particles, revealing a smooth shiny surface underneath. Further scraping produces small drops of blood. The papules rapidly enlarge, often coalescing to form plaques. This process may be circumscribed, disseminated, or generalized (erythroderma psoriaticum). When the papules and plaques reach a certain size, they stop growing and then harden, shrink, and disappear, leaving depigmented or hyperpigmented spots.

There are thus three stages of psoriasis: progressive (appearance and growth of papules), stationary (stable), and regressive (hardening and disappearance of papules). Sometimes the nail plates are affected, and their surface becomes thimble-like. In some patients, the eruptions are accompanied by swelling and tenderness of the joints (psoriasis anthropathica).

Treatment is effected by administering vitamins A, B1, B6, and B12, tranquilizers, and hormones, by means of ultraviolet radiation and application of paraffin and desquamative and resorbing ointments, and by health-resort therapy.


Mashkilleison, L. N. Chastnaia dermatologiia. Moscow, 1965. Pages 161–216.



A usually chronic, often acute inflammatory skin disease of unknown cause; characterized by dull red, well-defined lesions covered by silvery scales which when removed disclose tiny capillary bleeding points.


a skin disease characterized by the formation of reddish spots and patches covered with silvery scales: tends to run in families
References in periodicals archive ?
Methotrexate is not disease modifying in psoriatic arthritis: the MIPA trial.
The National Psoriasis Foundation puts people living with psoriatic disease at the center of everything we do.
Involvement of the distal mterpha-langeal (DIP) joints is a common feature in osteoarthritis as well as psoriatic arthritis.
PAPAA is a leading supplier of free patient information, covering all aspects of psoriasis and psoriatic arthritis.
Adalimumab, a fully human anti-TNF-a monoclonal antibody administered subcutaneously, 40 mg, every other week, was studied in the ADEPT (Adalimumab Effectiveness in Psoriatic Arthritis Trial (N = 313).
Taken together, the PALACE program is comprised of the most comprehensive psoriatic arthritis studies to date intended for regulatory submission.
This new grant program will address these issues by supporting projects focused on increasing the number of psoriatic disease patients aware of treatment options appropriate to their disease severity.
PRESTA was a 24-week, multicenter, randomized, double-blind clinical trial in 752 patients with both psoriasis evaluated by dermatologists and psoriatic arthritis evaluated by rheumatologists.
Between six and 42 per cent of people with psoriasis also suffer from psoriatic arthritis,(3) a debilitating condition that can cause pain, swelling and stiffness in the hands and feet, larger joints such as the hips and knees, or the spine.
35) If methotrexate is not well tolerated or causes persistent elevation of liver function tests, or if there is persistent disease activity (evidenced by persistent swollen and tender joints, morning stiffness, enthesopathy, psoriatic plaques, and fatigue, and certainly imaging evidence of progressive joint damage), current practice, depending on local treatment patterns and financial coverage, would be to add one of the parenteral anti-TNF agents.
The report provides estimates and forecasts of Psoriatic Arthritis prevalence, Psoriatic Arthritis diagnosis rate, and Psoriatic Arthritis treatment rate for the period 2012-2019.
These fellowships will help increase the number of scientists studying and expertly treating psoriatic disease by encouraging up-and-coming doctors to dedicate their careers to these conditions.