D-cycloserine and rapastinel significantly reduced depressive symptoms without psychotomimetic
and dissociative effects.
In fact, Manfred Bleuler claimed that psychotomimetic
drugs "contributed nothing to the understanding of the pathogenesis of schizophrenia" (Bleuler 1959 quoted in Grob 2002: 272).
One key issue is its safety and tolerability, with psychotomimetic
adverse effects being the major concern.
The influence of the [delta]-opioid receptors is not as well known, but they may have psychotomimetic
and dysphoric effects.
They're difficult to titrate, and if a patient gets too high a dose, agitation and psychotomimetic
effects can appear.
Absolute configuration and psychotomimetic
Patat A, Molinier P, Hergueta T, Brohier S, Zieleniuk I, Danjou P, Warot D, Puech A: Lack of amnestic, psychotomimetic
or impairing effect on psychomotor performance of eliprodil, a new NMDA antagonist.
Moreover, AV-101 administration was not associated with negative side effects usually attributed to ketamine, such as addictive preference, psychotomimetic
responses, and abnormal locomotor or movement behaviors.
Relationships of psychotomimetic
to anti-serotonin potencies of congeners of lysergic acid diethylamide (LSD-25).
BHV-0223 has significant potential to deliver efficacy without the psychotomimetic
effects that have been reported with ketamine," says Dr.
Lophophine is also closely related to MMDA, 3-methoxy-4,5-methylenedioxyamphetamine, which is a potent psychotomimetic
agent, first described in 1964 (Shulgin 1964).
Rapastinel was well-tolerated with no drug-related serious adverse events reported, including no sign of the psychotomimetic
, or psychosis-like, effects associated with NMDA receptor antagonists such as ketamine.