As a result of the large doses for extended periods of time, irrational behavior may occur, as well as fatigue, paranoia, and psychotomimetic
REL-1017 (dextromethadone) is an orally administered NMDA receptor (NMDAR) antagonist, which is active on the NMDAR ketamine binding site and has demonstrated an overall favorable safety profile without ketamine psychotomimetic
adverse reactions in two Phase 1 studies.
Impact of cannabidiol on the acute memory and psychotomimetic
effects of smoked cannabis: naturalistic study.
WAY 100135, an antagonist of 5-HT1A serotonin receptors, attenuates psychotomimetic
effects of MK-801.
Svensson TH: Dysfunctional brain dopamine systems induced by psychotomimetic
NMDA-receptor antagonists and the effects of antipsychotic drugs.
Most conventional nonselective NMDA receptor antagonists, however, have been implicated in adverse effects including psychotomimetic
effects, impairments of learning, memory, and dissociative anesthesia.
Acute memory and psychotomimetic
effects of cannabis and tobacco both 'joint' and individually: a placebo-controlled trial.Psychological Medicine .
Dysphoric reaction are less frequent and my include anxiety, fear, and psychotomimetic
symptoms, but these effects are generally transient and usually do not need medical intervention (16,18,20,21).
Unlike ketamine, GLYX-13 does not elicit psychotomimetic
Seibyl et al., "Subanesthetic effects of the noncompetitive nmda antagonist, ketamine, in humans: psychotomimetic
, perceptual, cognitive, and neuroendocrine responses," Archives of General Psychiatry, vol.
The link between glutamate, NMDAR, and schizophrenia was firstly suggested by psychotomimetic
symptoms induced by NMDAR noncompetitive antagonists, such as ketamine and phencyclidine, in healthy subjects .
In terms of drug class, ketamine can be categorized as a dissociative anesthetic, hallucinogen, and psychotomimetic