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Related to pustular psoriasis: guttate psoriasis


(sôrī`əsĭs), occasionally acute but usually chronic and recurrent inflammation of the skin. The exact cause is unknown, but the disease appears to be an inherited, possibly autoimmune disorder that causes the overproduction of skin cells. Psoriasis may occur at any age but is uncommon in children. The characteristic lesion is a scaly "mother-of-pearl" patch, appearing anywhere on the body. Involvement may range from a single plaque to numerous patches that cover most of the skin. A variety of treatments are used for patients with mild to moderate cases. Treatments directed at the symptoms include the application of ointments and exposure to sunlight and ultraviolet (UVB) light. Retinoids help stabilize follicular epithelial cells. Vitamin D analogs and metabolites, although effective in treatment, have side effects. Photochemotherapy (psoralen combined with UVA radiation) is also effective, but increases the risk of skin cancer. Alfacept and other drugs that interfere with T-cell (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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) activation, and etanercept, infliximab, and other drugs that block tumor-necrosis factor are effective in many patients with moderate to severe psoriasis.



a chronic recurrent noncontagious skin disease of man. Neuropsychic traumas and metabolic and endocrine disorders play a part in the development of psoriasis. The disease may also be viral or genetic in nature.

Eruptions may appear anywhere on the skin but generally occur on the elbows, knees, sacral region, and scalp. The disease becomes acute with the appearance of small pink-red papules covered with silvery scales that readily slough off. When the papules are scraped, the scales fall off in small particles, revealing a smooth shiny surface underneath. Further scraping produces small drops of blood. The papules rapidly enlarge, often coalescing to form plaques. This process may be circumscribed, disseminated, or generalized (erythroderma psoriaticum). When the papules and plaques reach a certain size, they stop growing and then harden, shrink, and disappear, leaving depigmented or hyperpigmented spots.

There are thus three stages of psoriasis: progressive (appearance and growth of papules), stationary (stable), and regressive (hardening and disappearance of papules). Sometimes the nail plates are affected, and their surface becomes thimble-like. In some patients, the eruptions are accompanied by swelling and tenderness of the joints (psoriasis anthropathica).

Treatment is effected by administering vitamins A, B1, B6, and B12, tranquilizers, and hormones, by means of ultraviolet radiation and application of paraffin and desquamative and resorbing ointments, and by health-resort therapy.


Mashkilleison, L. N. Chastnaia dermatologiia. Moscow, 1965. Pages 161–216.



A usually chronic, often acute inflammatory skin disease of unknown cause; characterized by dull red, well-defined lesions covered by silvery scales which when removed disclose tiny capillary bleeding points.


a skin disease characterized by the formation of reddish spots and patches covered with silvery scales: tends to run in families
References in periodicals archive ?
Types of Psoriasis Encountered Type of Psoriasis Total Chronic Plaque Psoriasis 34 Pustular Psoriasis 5 Chronic Plaque Psoriasis with arthritis 6 Guttate type of Psoriasis 6 Psoriatic Erythroderma 1 Table 14.
Successful treatment of severe generalized pustular psoriasis with basiliximab (interleukin-2 receptor blocker).
Clinically and histologically, APPP is indistinguishable from pustular psoriasis.
Generalised erythrodermic or generalised pustular psoriasis (emergency referral is indicated), or acute unstable psoriasis (urgent referral may be justified).
It's an important entity to recognize, because AGEP can have a sudden onset, with fevers and numerous widespread nonfollicular pustules, which can look a lot like pustular psoriasis," said Dr.
In a patient with severe pustular psoriasis who presented in 2001 with a significant flare that required hospitalization, infliximab (Remicade) treatment resulted in remarkable clearing (J.
Young increased her probability of success estimate for ANB-019 on generalized pustular psoriasis from 0% to 25% ahead of getting first patient data potentially in late 2018 or early 2019 and raised her probability of success on ANB-020 in peanut allergy from 10% to 25% ahead of upcoming proof of concept data.
Morphological variants of psoriasis include plaque type, guttate psoriasis, rupioid, ostraceous, elephantine psoriasis, pustular psoriasis and erythrodermic psoriasis.
IL20 and IL22 are involved in proliferation and differentiation of keratinocytes (skin cells) and when over-expressed, are implicated in autoimmune diseases of the skin, including atopic dermatitis, psoriasis and pustular psoriasis.