The experimental groups were divided according to the presence of Chagas disease and the administration of pyridostigmine bromide
during the month from the 5th to the 6th month of observation (chronic phase), as described below.
(36) Pyridostigmine bromide
acts to supplement post-exposure
Central nervous system injury has been reported in research animals exposed to pyridostigmine bromide
, DEET (N,N-diethyl-m-toluamide), and permethrin (Abou-Donia et al.
All of the MG mothers who gave birth to children with severe birth defects had used the anticholinesterase drug pyridostigmine bromide
250,000 troops received the drug pyridostigmine bromide
, which a Pentagon-funded Rand Corporation study "cannot rule out" as linked to Gulf war illnesses.
'At first they said they had given me pretreatment - a course of 30 tablets of pyridostigmine bromide
. When I challenged that they came to the conclusion that actually they hadn't.'
The first time this issue arose in the recent past was during the Gulf War, when the FDA struggled with allowing the use by troops of pyridostigmine bromide
and botulinum toxoid as pretreatments for possible biological warfare agents without FDA approval of the products for that purpose.
(PB), an anti-nerve gas drug given to Gulf War troops on an "investigational" basis, is the third possibility.
Here, too, the military was lacking in up-to-date research or effective antidotes, so in desperation, it latched on to a drug called pyridostigmine bromide
(PB), which is approved by the Food and Drug Administration only for treatment of the neurological disorder myasthenia gravis.
Ross Perot, explored whether the syndrome could result from wartime exposure to the pesticides DEET and permethrin, which were used to protect troops from malaria and other insect-borne diseases, or an anti-nerve-gas agent called pyridostigmine bromide
, which was widely used in the Gulf War.
Back then he approved the use of pyridostigmine bromide
, an experimental drug issued to soldiers as a "pretreatment" against the effects of a possible nerve gas attack.