pyridoxal phosphate

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pyridoxal phosphate

(pĭr'ĭdŏks`əl): see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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; vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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.

pyridoxal phosphate

[‚pir·ə′däk·səl ′fä‚sfāt]
(biochemistry)
References in periodicals archive ?
Low pyridoxal 5'-phosphate is associated with increased risk of coronary artery disease.
"Many physiologically important enzymes in Stapylococcus depend on pyridoxal phosphate.
In addition to PLP, some laboratories report PA, the metabolite of pyridoxal, and the PLPto-PA ratio (2).
Abbreviations AdoMet: s-Adenosyl-L-methionine CBS: Cystathionine [beta]-synthase CBSA 409-551: Truncated cystathionine [beta]-synthase lacking the C-terminal 143 residues CBS p.P49L: Cystathionine [beta]-synthase variant harboring a proline-to-leucine substitution at residue 49 CO: Carbon monoxide CSE: Cystathionine y-lyase EDTA: Ethylenediaminetetraacetic acid [H.sub.2]S: Hydrogen sulfide KPi: Potassium phosphate MME: Monomethyl ether MST: Mercaptopyruvate sulfurtransferase NO[??]: Nitric oxide PEG: Polyethylene glycol PLP: Pyridoxal 5-phosphate r.m.s.d.: Root mean square deviation SDS-PAGE: Sodium dodecyl sulfate polyacrylamide gel electrophoresis WT: Wild type.
Toney, "Pyridoxal phosphate enzymology," Biochimica et Biophysica Acta, vol.
A novel chemical defined medium (SDM) was developed (Table 1 and Figures 3, 4, and 5), and SDM contained NaCl, L-Arg, L-Gly, L-His, L-Leu, L-Met, L-Phe, L-Thr, L-Ser, L-Cys, L-Asn, L-Glu, L-Iso, L-Lys, L-Try, pyridoxal, pantothenic acid, niacin, riboflavin, folic acid, MgS[O.sub.4]-7[H.sub.2]O, MnS[O.sub.4] x 4[H.sub.2]O, K[H.sub.2]P[O.sub.4], [K.sub.2]HP[O.sub.4], C[H.sub.3]COONa, adenine, and uracil.
Selhub, "Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 status," Journal of Nutrition, vol.
Pyridoxal can be converted to pyridoxal phosphate, which can work as coenzyme to participate in the synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, 5-aminolevulinic acid, and so forth.
Alanine aminotransferase kit {(International Federation of Clinical Chemistry (IFCC)} without pyridoxal phosphate activation.
Relationship between pyridoxal 5'- phosphate deficiency and aminotransferase levels in alcoholic hepatitis.
Each subunit tightly attaches to one molecule of pyridoxal 5'-phosphate.