* Patients with coronary artery disease have, on average, 34.2% lower levels of the bioactive form of B6 (pyridoxal 5'-phosphate
) compared to those without heart problems, which may relate to its role in lowering homocysteine.
Vitamin [B.sub.6] and its derivative pyridoxal 5'-phosphate
(PLP) are essential to over 100 enzymes, most of which are involved in protein metabolism.
GAD is a pyridoxal 5'-phosphate
(PLP) dependent enzyme, which catalyzes the irreversible decarboxylation of L-glutamic acid to gamma-aminobutyric acid (GABA) and carbon dioxide.
 Nonstandard abbreviations: ALP, alkaline phosphatase; PLP, pyridoxal 5'-phosphate
; PA, pyridoxic acid; HPP, hypophosphatasia; TNSALP, tissue-nonspecific isoenzyme of alkaline phosphatase; PPi, inorganic pyrophosphate.
Selhub, "Plasma pyridoxal 5'-phosphate
concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 status," Journal of Nutrition, vol.
Selhub, "Mechanistic perspective on the relationship between pyridoxal 5'-phosphate
and inflammation," Nutrition Reviews, vol.
Chronic alcoholics are often deficient in pyridoxal 5'-phosphate
(vitamin [B.sub.6]), which is a necessary coenzyme for both ALT and ALT synthesis.
Each subunit tightly attaches to one molecule of pyridoxal 5'-phosphate
. Secondary structures identified in the protein motif region, which is graphical represented as a split-barrel structure.
(PLP) is an essential cofactor in all living systems and participates in catalysis by a wide diversity of enzymes including oxidoreductases, transferases, hydrolases, lyases, isomerases.
At the supplier level Pamlab LLC, developer and marketer of Metanx, reported earlier this year that a multicenter study, done in collaboration with Tulane University and published in The American Journal of Medicine, suggests that nutritional management of diabetic peripheral neuropathy (DPN) with L-methylfolate, methylcobalamin and pyridoxal 5'-phosphate
, a prescription medical food dispensed and commercially known as Metanx, improves total symptoms and health-related quality of life.
Radiographic evidence of skeletal mineralization was associated with reduced plasma levels of pyridoxal 5'-phosphate
and increased levels of parathyroid hormone, which was initially suppressed in all patients.
submitted a citizen petition to the US Food and Drug Administration (FDA), asserting that dietary supplements containing pyridoxal 5'-phosphate
(P5P) "are adulterated and are being unlawfully marketed." P5P is vitamin B6's bioactive form.