pyridoxal phosphate

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pyridoxal phosphate

(pĭr'ĭdŏks`əl): see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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; vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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.
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pyridoxal phosphate

[‚pir·ə′däk·səl ′fä‚sfāt]
(biochemistry)
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Homocysteine levels can be determined by a simple blood test and lowered with the proper forms of B6 (pyridoxal 5-phosphate), B12 (as methylcobalamin), folate (as 5-methyltetrahydrofolate), and vitamin B2 (riboflavin-5-phosphate).
O'Reilly, "Optimisation and validation of a sensitive high-performance liquid chromatography assay for routine measurement of pyridoxal 5-phosphate in human plasma and red cells using pre-column semicarbazide derivatisation," Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol.
The active site of the pyridoxal 5'-phosphate is in a fastened conformation because, the absence of pyridoxal 5-phosphate. After substrate binds to the receptor molecule and is converted to PLP.
Pyridoxine is converted by all organs of the body to pyridoxal 5-phosphate (PLP) and pyridoxamine, which serve as coenzymes for transaminase reaction [13].
A randomized multicenter trial (N=214) found that adding a supplement containing L-methylfolate 3 mg, pyridoxal 5-phosphate 35 mg, and methylcobalamin 2 mg twice daily to other medications (eg, pregabalin, gabapentin, or duloxetine) improved symptoms of diabetic neuropathy.
As for B2 and B6, the most active forms are riboflavin 5-phosphate and pyridoxal 5-phosphate, respectively.
The reaction mixture consisting of 1 mM L-lysine HCl, 1mM [alpha]-ketoglutarate, 15 [micro]M pyridoxal 5-phosphate, and 1.25 pM MtLAT in a final volume of 200 [mciro]L diluted in 200 mM phosphate buffer (pH 7.2) was added to each well of a 96-well plate.
Among this subset, Wei and her team analyzed blood samples collected in 1989, looking for levels of a substance called PLP (pyridoxal 5-phosphate) -- the main active form of vitamin B6 in the blood.
They found that vitamin B6 (pyridoxal 5-phosphate) is significantly lower in people and animals with rheumatoid arthritis.
Purified serine racemase has a molecular weight of 37 kDa and requires pyridoxal 5-phosphate for its activity.